Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects

Minkyung Kim, Minjoo Kim, Young Ju Lee, Sung Pyo Lee, Tae Su Kim, Hye Jeong Yang, Dae Young Kwon, Sang Hyun Lee, Jong Ho Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalJournal of Functional Foods
Volume23
DOIs
Publication statusPublished - 2016 May 1

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1-Alkyl-2-acetylglycerophosphocholine Esterase
thromboplastin
phospholipase A2
alpha-Linolenic Acid
Partial Thromboplastin Time
epinephrine
linolenic acid
lipoproteins
Epinephrine
collagen
Collagen
low density lipoprotein cholesterol
LDL Cholesterol
placebos
Placebos
oxen
Apolipoproteins B
Hemostatics
Cholesterol
cholesterol

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects",
abstract = "We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).",
author = "Minkyung Kim and Minjoo Kim and Lee, {Young Ju} and Lee, {Sung Pyo} and Kim, {Tae Su} and Yang, {Hye Jeong} and Kwon, {Dae Young} and Lee, {Sang Hyun} and Lee, {Jong Ho}",
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Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects. / Kim, Minkyung; Kim, Minjoo; Lee, Young Ju; Lee, Sung Pyo; Kim, Tae Su; Yang, Hye Jeong; Kwon, Dae Young; Lee, Sang Hyun; Lee, Jong Ho.

In: Journal of Functional Foods, Vol. 23, 01.05.2016, p. 95-104.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects

AU - Kim, Minkyung

AU - Kim, Minjoo

AU - Lee, Young Ju

AU - Lee, Sung Pyo

AU - Kim, Tae Su

AU - Yang, Hye Jeong

AU - Kwon, Dae Young

AU - Lee, Sang Hyun

AU - Lee, Jong Ho

PY - 2016/5/1

Y1 - 2016/5/1

N2 - We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).

AB - We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).

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