Abstract
We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).
| Original language | English |
|---|---|
| Pages (from-to) | 95-104 |
| Number of pages | 10 |
| Journal | Journal of Functional Foods |
| Volume | 23 |
| DOIs | |
| Publication status | Published - 2016 May 1 |
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All Science Journal Classification (ASJC) codes
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
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Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects. / Kim, Minkyung; Kim, Minjoo; Lee, Young Ju; Lee, Sung Pyo; Kim, Tae Su; Yang, Hye Jeong; Kwon, Dae Young; Lee, Sang Hyun; Lee, Jong Ho.
In: Journal of Functional Foods, Vol. 23, 01.05.2016, p. 95-104.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects
AU - Kim, Minkyung
AU - Kim, Minjoo
AU - Lee, Young Ju
AU - Lee, Sung Pyo
AU - Kim, Tae Su
AU - Yang, Hye Jeong
AU - Kwon, Dae Young
AU - Lee, Sang Hyun
AU - Lee, Jong Ho
PY - 2016/5/1
Y1 - 2016/5/1
N2 - We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).
AB - We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov: NCT02609295; http://www.clinicaltrials.gov).
UR - http://www.scopus.com/inward/record.url?scp=84959346372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959346372&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2016.02.026
DO - 10.1016/j.jff.2016.02.026
M3 - Article
VL - 23
SP - 95
EP - 104
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -