Effects of α-melanocyte-stimulating hormone on calcium concentration in SZ95 sebocytes

Sung Won Whang, Sang Eun Lee, Ji Min Kim, Hyun Jung Kim, Se Kyoo Jeong, Christos C. Zouboulis, Jeong Taek Seo, Seung Hun Lee

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Melanocortins have been implicated in human sebum secretion for a long time. However, the signalling pathways of α-melanocyte-stimulating hormone (α-MSH) in human sebocytes expressing melanocortin receptors (MC-Rs) are still poorly understood. Because calcium ions play a central role in MC-R signalling, we investigated whether α-MSH affects calcium signalling in the immortalized human sebocyte cell line SZ95. In addition, we investigated the impact of α-MSH on MC-1R expression and lipid synthesis in these cells. α-MSH increased intracellular calcium levels. α-MSH-mediated calcium mobilization originated from intracellular calcium stores and was mediated by inositol triphosphate. Moreover, α-MSH increased MC-1R immunoreactivity and lipid synthesis in SZ95 sebocytes in the presence of testosterone. Our data demonstrate that α-MSH in human sebocytes controls a key cellular signalling pathway, the calcium ion response, which may coordinate MC-1R-mediated sebum secretion.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalExperimental dermatology
Volume20
Issue number1
DOIs
Publication statusPublished - 2011 Jan

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

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