Effects of β-glucan on proliferation and migration of fibroblasts

Hyun Joo Son, Hyun Chul Bae, Hyun Jeong Kim, Dong Hee Lee, Dong Wook Han, Jong Chul Park

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

β-Glucans, originated from the outer cell wall of fungi, are shown to have immune stimulatory activity, especially to enhance wound healing. In the wound healing processes, the migration and proliferation of fibroblasts are essential. Actually fetal and neonatal wounds heal without scar because the migration of those dermal fibroblasts is faster than that of adult fibroblasts. Furthermore, it has been reported that human dermal fibroblasts express receptors for β-glucans like macrophages. In this study, the direct effects of β-glucans on the proliferation and migration of L-929 fibroblasts were examined in vitro. β-Glucan treatment to the L-929 cells with 0.5 or 5 mg/ml resulted in a significant (p < 0.05) dose-dependant increase in cell proliferation. However, the migration assay using a self-designed cell tracking system showed that there was no significant difference in the migration speed between the glucan-treated and non-treated cells. These results suggest that β-glucans can enhance directly fibroblast proliferation in vitro, but not affect fibroblast migration.

Original languageEnglish
Pages (from-to)468-471
Number of pages4
JournalCurrent Applied Physics
Volume5
Issue number5
DOIs
Publication statusPublished - 2005 Jul

Bibliographical note

Funding Information:
This study was supported by the Ministry of Science and Technology of the Republic of Korea (Grant no. R01-2004-000-10580-0).

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)

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