Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation

Yeon I. Woo, Hyun Joo Son, Hye Ryeon Lim, Mi Hee Lee, Hyun Sook Baek, Kazufumi Tsubaki, Jong Chul Park

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Abstract

Glucans have been reported to stimulate immunity and to promote wound healing. Adult human dermal fibroblast (aHDF) cultured in serum free (serum-starvation). Proliferation of aHDF was measured at various concentrations of β-glucan by MTT assay, and migration was observed for 36h on microscope. The result of fibroblast bioassay, β-glucan had positive influence. In this study, the direct effects of β-glucan on proliferation and migration of human dermal fibroblasts were examined in vitro. That means β-D-glucan has the effect to enhance proliferation and aHDF migration speed, and has the potential as a wound healing agent.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Woo, Y. I., Son, H. J., Lim, H. R., Lee, M. H., Baek, H. S., Tsubaki, K., & Park, J. C. (2007). Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation. Key Engineering Materials, 342-343, 401-404.