Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation

Yeon I. Woo, Hyun Joo Son, Hye Ryeon Lim, Mi Hee Lee, Hyun Sook Baek, Kazufumi Tsubaki, Jongchul Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glucans have been reported to stimulate immunity and to promote wound healing. Adult human dermal fibroblast (aHDF) cultured in serum free (serum-starvation). Proliferation of aHDF was measured at various concentrations of β-glucan by MTT assay, and migration was observed for 36h on microscope. The result of fibroblast bioassay, β-glucan had positive influence. In this study, the direct effects of β-glucan on proliferation and migration of human dermal fibroblasts were examined in vitro. That means β-D-glucan has the effect to enhance proliferation and aHDF migration speed, and has the potential as a wound healing agent.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16

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Fibroblasts
Glucans
Cells
Bioassay
Assays
Microscopes
polyglucosan

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Woo, Y. I., Son, H. J., Lim, H. R., Lee, M. H., Baek, H. S., Tsubaki, K., & Park, J. (2007). Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation. Key Engineering Materials, 342-343, 401-404.
Woo, Yeon I. ; Son, Hyun Joo ; Lim, Hye Ryeon ; Lee, Mi Hee ; Baek, Hyun Sook ; Tsubaki, Kazufumi ; Park, Jongchul. / Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation. In: Key Engineering Materials. 2007 ; Vol. 342-343. pp. 401-404.
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Woo, YI, Son, HJ, Lim, HR, Lee, MH, Baek, HS, Tsubaki, K & Park, J 2007, 'Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation', Key Engineering Materials, vol. 342-343, pp. 401-404.

Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation. / Woo, Yeon I.; Son, Hyun Joo; Lim, Hye Ryeon; Lee, Mi Hee; Baek, Hyun Sook; Tsubaki, Kazufumi; Park, Jongchul.

In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 401-404.

Research output: Contribution to journalArticle

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T1 - Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation

AU - Woo, Yeon I.

AU - Son, Hyun Joo

AU - Lim, Hye Ryeon

AU - Lee, Mi Hee

AU - Baek, Hyun Sook

AU - Tsubaki, Kazufumi

AU - Park, Jongchul

PY - 2007/4/16

Y1 - 2007/4/16

N2 - Glucans have been reported to stimulate immunity and to promote wound healing. Adult human dermal fibroblast (aHDF) cultured in serum free (serum-starvation). Proliferation of aHDF was measured at various concentrations of β-glucan by MTT assay, and migration was observed for 36h on microscope. The result of fibroblast bioassay, β-glucan had positive influence. In this study, the direct effects of β-glucan on proliferation and migration of human dermal fibroblasts were examined in vitro. That means β-D-glucan has the effect to enhance proliferation and aHDF migration speed, and has the potential as a wound healing agent.

AB - Glucans have been reported to stimulate immunity and to promote wound healing. Adult human dermal fibroblast (aHDF) cultured in serum free (serum-starvation). Proliferation of aHDF was measured at various concentrations of β-glucan by MTT assay, and migration was observed for 36h on microscope. The result of fibroblast bioassay, β-glucan had positive influence. In this study, the direct effects of β-glucan on proliferation and migration of human dermal fibroblasts were examined in vitro. That means β-D-glucan has the effect to enhance proliferation and aHDF migration speed, and has the potential as a wound healing agent.

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Woo YI, Son HJ, Lim HR, Lee MH, Baek HS, Tsubaki K et al. Effects of (1→3), (1→6)-β-D-glucan behavior in human dermal fibroblast cells under serum starvation. Key Engineering Materials. 2007 Apr 16;342-343:401-404.