Effects of a chitosan membrane coated with polylactic and polyglycolic acid on bone regeneration in a rat calvarial defect

Ui Won Jung, Kun Young Song, Chang Sung Kim, Yong Keun Lee, Kyoo Sung Cho, Chong Kwan Kim, Seong Ho Choi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the effects of a chitosan membrane coated with polylactic and polyglycolic acid (PLGA) on bone regeneration in a rat calvarial defect. Surgical implantation of chitosan membranes resulted in enhanced local bone formation at both 2 and 8 weeks. In conclusion, the chitosan membrane coated with PLGA had a significant potential to induce bone formation in the rat calvarial defect model. Within the selected PLGA dose range and observation intervals, there appeared to be no meaningful differences in bone formation.

Original languageEnglish
Article numberS03
JournalBiomedical Materials
Volume2
Issue number3
DOIs
Publication statusPublished - 2007 Sep 1

Fingerprint

Polyglycolic Acid
Chitosan
Rats
Bone
Membranes
Defects
Acids
poly(lactic acid)

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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abstract = "The purpose of this study was to evaluate the effects of a chitosan membrane coated with polylactic and polyglycolic acid (PLGA) on bone regeneration in a rat calvarial defect. Surgical implantation of chitosan membranes resulted in enhanced local bone formation at both 2 and 8 weeks. In conclusion, the chitosan membrane coated with PLGA had a significant potential to induce bone formation in the rat calvarial defect model. Within the selected PLGA dose range and observation intervals, there appeared to be no meaningful differences in bone formation.",
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Effects of a chitosan membrane coated with polylactic and polyglycolic acid on bone regeneration in a rat calvarial defect. / Jung, Ui Won; Song, Kun Young; Kim, Chang Sung; Lee, Yong Keun; Cho, Kyoo Sung; Kim, Chong Kwan; Choi, Seong Ho.

In: Biomedical Materials, Vol. 2, No. 3, S03, 01.09.2007.

Research output: Contribution to journalArticle

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AU - Choi, Seong Ho

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