Effects of Alzheimer's disease and Lewy body disease on subcortical atrophy

H. S. Yoo, E. C. Lee, S. J. Chung, Y. H. Lee, S. G. Lee, M. Yun, P. H. Lee, Y. H. Sohn, J. K. Seong, B. S. Ye

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Abstract

Background and purpose: Subcortical structures are affected by neurodegeneration in Alzheimer's disease (AD) and Lewy body disease (LBD). Although the co-occurrence of AD and LBD pathologies and their possible interaction have been reported, the effect of AD and LBD on subcortical structures remains unknown. The effects of AD and LBD on subcortical atrophy and their relationship with cognitive dysfunction were investigated. Methods: The cross-sectional study recruited 42 patients with pure AD related cognitive impairment (ADCI), 30 patients with pure LBD related cognitive impairment (LBCI), 58 patients with mixed ADCI and LBCI, and 29 normal subjects. A general linear model was used to compare subcortical volume and shape amongst the groups, to investigate the independent and interaction effects of ADCI and LBCI on subcortical shape and volume, and to analyze the relationship between subcortical volume and cognitive dysfunction in each group. Results: Alzheimer's disease related cognitive impairment and LBCI were independently associated with subcortical atrophies in the hippocampus and amygdala and in the hippocampus and putamen respectively, but their interaction effect was not significant. Compared to the control group, the pure LBCI group exhibited additional local atrophies in the amygdala, caudate and thalamus. Subcortical atrophies correlated differently with cognitive dysfunction according to the underlying causes of cognitive dysfunction. Conclusions: The patterns of subcortical atrophies and their correlation with cognitive dysfunction differ according to the underlying AD, LBD or concomitant AD and LBD.

Original languageEnglish
Pages (from-to)318-326
Number of pages9
JournalEuropean Journal of Neurology
Volume27
Issue number2
DOIs
Publication statusPublished - 2020 Feb 1

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Yoo, H. S., Lee, E. C., Chung, S. J., Lee, Y. H., Lee, S. G., Yun, M., Lee, P. H., Sohn, Y. H., Seong, J. K., & Ye, B. S. (2020). Effects of Alzheimer's disease and Lewy body disease on subcortical atrophy. European Journal of Neurology, 27(2), 318-326. https://doi.org/10.1111/ene.14080