Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia

Byoung Seok Ye, Sang Won Seo, Jung Hyun Kim, Geon Ha Kim, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W. Yoon, Sook Young Woo, Sook Hui Kim, Hee Kyung Park, Sung Tae Kim, Yearn Seong Choe, Kyung Han Lee, Jae Seung Kim, Seung Jun Oh, Changsoo Kim, Michael Weiner, Jae Hong Lee, Duk L. Na

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Abstract

Objective: To determine the independent and synergistic effects of amyloid and small vessel disease (SVD) burden on longitudinal cognitive decline in patients with subcortical vascular dementia (SVaD). Methods: A longitudinal cohort study was conducted involving patients from outpatient clinics of 2 tertiary referral centers. Sixty-one patients with SVaD were prospectively recruited and underwent MRI, 11C-Pittsburgh compound B (PiB) PET at baseline, and a 3-year annual neuropsychological follow-up. Effects of PiB positivity and SVD markers (white matter hyperintensities [WMH], lacunes, and microbleeds) on longitudinal cognitive decline were evaluated using generalized estimation equation after controlling for age, sex, education, APOE4 allele, and follow-up interval. Results: When individual neuropsychological tests were used as outcome measures, PiB positivity was associated with faster cognitive decline in attention, visuospatial, visual memory, and global cognition function. Higher WMH burden was associated with faster cognitive decline in attention, visuospatial, visual recognition memory, and semantic/phonemic fluency function, whereas lacunes and microbleeds had no significant effects. When global dementia rating (Clinical Dementia Rating sum of boxes) was considered as an outcome measure, however, only PiB positivity was associated with faster cognitive decline. Significant interactions between PiB positivity and higher SVD burden were found to affect cognitive decline in semantic word fluency (from WMH burden) and global dementia rating (from microbleed burden). Conclusions: In SVaD patients, amyloid burden, independently or interactively with SVD, contributed to longitudinal cognitive decline. Amyloid deposition was the strongest poor prognostic factor.

Original languageEnglish
Pages (from-to)1687-1693
Number of pages7
JournalNeurology
Volume85
Issue number19
DOIs
Publication statusPublished - 2015 Nov 10

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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    Ye, B. S., Seo, S. W., Kim, J. H., Kim, G. H., Cho, H., Noh, Y., Kim, H. J., Yoon, C. W., Woo, S. Y., Kim, S. H., Park, H. K., Kim, S. T., Choe, Y. S., Lee, K. H., Kim, J. S., Oh, S. J., Kim, C., Weiner, M., Lee, J. H., & Na, D. L. (2015). Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia. Neurology, 85(19), 1687-1693. https://doi.org/10.1212/WNL.0000000000002097