Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: Astudy among patients with subcortical vascular cognitive impairment

Hee Jin Kim, Byoung Seok Ye, Cindy W. Yoon, Hanna Cho, Young Noh, Geon Ha Kim, Yae Seul Choi, Jung Hyun Kim, Seun Jeon, Jong Min Lee, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Sung Tae Kim, Changsoo Kim, Dae Ryong Kang, Chang Seok Ki, Jae Hong Lee, David J. Werring, Michael W. WeinerDuk L. Na, Sang Won Seo

Research output: Contribution to journalArticle

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Abstract

The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95% confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95% CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95% CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease.

Original languageEnglish
Pages (from-to)2482-2487
Number of pages6
JournalNeurobiology of Aging
Volume34
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1

Fingerprint

Apolipoprotein E4
Lacunar Stroke
Amyloid
Blood Vessels
Alleles
Brain
Cerebrovascular Disorders
Odds Ratio
Confidence Intervals
Regression Analysis
Cognitive Dysfunction
White Matter
Cognition
Linear Models
Alzheimer Disease
Logistic Models

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Kim, Hee Jin ; Ye, Byoung Seok ; Yoon, Cindy W. ; Cho, Hanna ; Noh, Young ; Kim, Geon Ha ; Choi, Yae Seul ; Kim, Jung Hyun ; Jeon, Seun ; Lee, Jong Min ; Kim, Jae Seung ; Choe, Yearn Seong ; Lee, Kyung Han ; Kim, Sung Tae ; Kim, Changsoo ; Kang, Dae Ryong ; Ki, Chang Seok ; Lee, Jae Hong ; Werring, David J. ; Weiner, Michael W. ; Na, Duk L. ; Seo, Sang Won. / Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions : Astudy among patients with subcortical vascular cognitive impairment. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 11. pp. 2482-2487.
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abstract = "The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95{\%} confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95{\%} CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95{\%} CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease.",
author = "Kim, {Hee Jin} and Ye, {Byoung Seok} and Yoon, {Cindy W.} and Hanna Cho and Young Noh and Kim, {Geon Ha} and Choi, {Yae Seul} and Kim, {Jung Hyun} and Seun Jeon and Lee, {Jong Min} and Kim, {Jae Seung} and Choe, {Yearn Seong} and Lee, {Kyung Han} and Kim, {Sung Tae} and Changsoo Kim and Kang, {Dae Ryong} and Ki, {Chang Seok} and Lee, {Jae Hong} and Werring, {David J.} and Weiner, {Michael W.} and Na, {Duk L.} and Seo, {Sang Won}",
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Kim, HJ, Ye, BS, Yoon, CW, Cho, H, Noh, Y, Kim, GH, Choi, YS, Kim, JH, Jeon, S, Lee, JM, Kim, JS, Choe, YS, Lee, KH, Kim, ST, Kim, C, Kang, DR, Ki, CS, Lee, JH, Werring, DJ, Weiner, MW, Na, DL & Seo, SW 2013, 'Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: Astudy among patients with subcortical vascular cognitive impairment', Neurobiology of Aging, vol. 34, no. 11, pp. 2482-2487. https://doi.org/10.1016/j.neurobiolaging.2013.05.009

Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions : Astudy among patients with subcortical vascular cognitive impairment. / Kim, Hee Jin; Ye, Byoung Seok; Yoon, Cindy W.; Cho, Hanna; Noh, Young; Kim, Geon Ha; Choi, Yae Seul; Kim, Jung Hyun; Jeon, Seun; Lee, Jong Min; Kim, Jae Seung; Choe, Yearn Seong; Lee, Kyung Han; Kim, Sung Tae; Kim, Changsoo; Kang, Dae Ryong; Ki, Chang Seok; Lee, Jae Hong; Werring, David J.; Weiner, Michael W.; Na, Duk L.; Seo, Sang Won.

In: Neurobiology of Aging, Vol. 34, No. 11, 01.11.2013, p. 2482-2487.

Research output: Contribution to journalArticle

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T1 - Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions

T2 - Astudy among patients with subcortical vascular cognitive impairment

AU - Kim, Hee Jin

AU - Ye, Byoung Seok

AU - Yoon, Cindy W.

AU - Cho, Hanna

AU - Noh, Young

AU - Kim, Geon Ha

AU - Choi, Yae Seul

AU - Kim, Jung Hyun

AU - Jeon, Seun

AU - Lee, Jong Min

AU - Kim, Jae Seung

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Kim, Sung Tae

AU - Kim, Changsoo

AU - Kang, Dae Ryong

AU - Ki, Chang Seok

AU - Lee, Jae Hong

AU - Werring, David J.

AU - Weiner, Michael W.

AU - Na, Duk L.

AU - Seo, Sang Won

PY - 2013/11/1

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N2 - The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95% confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95% CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95% CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease.

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