The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95% confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95% CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95% CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease.
|Number of pages||6|
|Journal||Neurobiology of Aging|
|Publication status||Published - 2013 Nov|
Bibliographical noteFunding Information:
This study was supported by grants from the Korean Healthcare Technology R&D Project, the Ministry for Health, Welfare & Family Affairs, the Republic of Korea (nos. A102065 and A070001 ), by the Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011-0028333 ), by Samsung Medical Center Clinical Research Development Program grants ( CRL-108011 and CRS 110-14-1 ), and by the Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ).
Dr Seo and Dr Na receive research support from the Ministry of Health and Welfare, Korea.
All Science Journal Classification (ASJC) codes
- Developmental Biology
- Clinical Neurology
- Geriatrics and Gerontology