Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

Jae Hyun Park, Sang Won Seo, Changsoo Kim, Sook Hui Kim, Geon Ha Kim, Sung Tae Kim, Seun Jeon, Jong Min Lee, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Ji Soo Shin, Chi Hun Kim, Young Noh, Hanna Cho, Cindy W. Yoon, Hee Jin Kim, Byoung Seok Ye, Michael EwersMichael W. Weiner, Jae Hong Lee, David J. Werring, Duk L. Na

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalNeurobiology of Aging
Volume35
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Cerebrovascular Disorders
Amyloid
Cognition
Blood Vessels
Positron-Emission Tomography
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Cognitive Dysfunction
Magnetic Resonance Imaging
Retention (Psychology)
Pathology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Park, Jae Hyun ; Seo, Sang Won ; Kim, Changsoo ; Kim, Sook Hui ; Kim, Geon Ha ; Kim, Sung Tae ; Jeon, Seun ; Lee, Jong Min ; Oh, Seung Jun ; Kim, Jae Seung ; Choe, Yearn Seong ; Lee, Kyung Han ; Shin, Ji Soo ; Kim, Chi Hun ; Noh, Young ; Cho, Hanna ; Yoon, Cindy W. ; Kim, Hee Jin ; Ye, Byoung Seok ; Ewers, Michael ; Weiner, Michael W. ; Lee, Jae Hong ; Werring, David J. ; Na, Duk L. / Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment. In: Neurobiology of Aging. 2014 ; Vol. 35, No. 1. pp. 254-260.
@article{47b3b2d730094044b7ea4cf16778d71d,
title = "Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment",
abstract = "Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.",
author = "Park, {Jae Hyun} and Seo, {Sang Won} and Changsoo Kim and Kim, {Sook Hui} and Kim, {Geon Ha} and Kim, {Sung Tae} and Seun Jeon and Lee, {Jong Min} and Oh, {Seung Jun} and Kim, {Jae Seung} and Choe, {Yearn Seong} and Lee, {Kyung Han} and Shin, {Ji Soo} and Kim, {Chi Hun} and Young Noh and Hanna Cho and Yoon, {Cindy W.} and Kim, {Hee Jin} and Ye, {Byoung Seok} and Michael Ewers and Weiner, {Michael W.} and Lee, {Jae Hong} and Werring, {David J.} and Na, {Duk L.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.neurobiolaging.2013.06.026",
language = "English",
volume = "35",
pages = "254--260",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "1",

}

Park, JH, Seo, SW, Kim, C, Kim, SH, Kim, GH, Kim, ST, Jeon, S, Lee, JM, Oh, SJ, Kim, JS, Choe, YS, Lee, KH, Shin, JS, Kim, CH, Noh, Y, Cho, H, Yoon, CW, Kim, HJ, Ye, BS, Ewers, M, Weiner, MW, Lee, JH, Werring, DJ & Na, DL 2014, 'Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment', Neurobiology of Aging, vol. 35, no. 1, pp. 254-260. https://doi.org/10.1016/j.neurobiolaging.2013.06.026

Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment. / Park, Jae Hyun; Seo, Sang Won; Kim, Changsoo; Kim, Sook Hui; Kim, Geon Ha; Kim, Sung Tae; Jeon, Seun; Lee, Jong Min; Oh, Seung Jun; Kim, Jae Seung; Choe, Yearn Seong; Lee, Kyung Han; Shin, Ji Soo; Kim, Chi Hun; Noh, Young; Cho, Hanna; Yoon, Cindy W.; Kim, Hee Jin; Ye, Byoung Seok; Ewers, Michael; Weiner, Michael W.; Lee, Jae Hong; Werring, David J.; Na, Duk L.

In: Neurobiology of Aging, Vol. 35, No. 1, 01.01.2014, p. 254-260.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment

AU - Park, Jae Hyun

AU - Seo, Sang Won

AU - Kim, Changsoo

AU - Kim, Sook Hui

AU - Kim, Geon Ha

AU - Kim, Sung Tae

AU - Jeon, Seun

AU - Lee, Jong Min

AU - Oh, Seung Jun

AU - Kim, Jae Seung

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Shin, Ji Soo

AU - Kim, Chi Hun

AU - Noh, Young

AU - Cho, Hanna

AU - Yoon, Cindy W.

AU - Kim, Hee Jin

AU - Ye, Byoung Seok

AU - Ewers, Michael

AU - Weiner, Michael W.

AU - Lee, Jae Hong

AU - Werring, David J.

AU - Na, Duk L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

AB - Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

UR - http://www.scopus.com/inward/record.url?scp=84885188433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885188433&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2013.06.026

DO - 10.1016/j.neurobiolaging.2013.06.026

M3 - Article

C2 - 23932881

AN - SCOPUS:84885188433

VL - 35

SP - 254

EP - 260

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 1

ER -