Abstract
Background: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. Methods: We analyzed 8717 subjects with normal renal function recruited from the Korean Genome and Epidemiology Study (KoGES) cohort. Based on a food frequency questionnaire, coffee consumption was categorized into 5 groups: 0 per week, <1 cup per week, 1-6 cups per week, 1 cup per day, and ≥2 cups per day. The primary outcome was incident chronic kidney disease, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2. Results: The mean age (standard deviation) of study subjects was 52.0 (8.8) years, and 47.8% were male. Among the subjects, 52.8% were daily coffee consumers. During a mean follow-up of 11.3 (range, 5.9-11.5) years, 9.5% of participants developed chronic kidney disease. The incident chronic kidney disease occurred less in daily coffee consumers. Unadjusted hazard ratios (HRs) was significantly lower in daily coffee consumers. In multivariable Cox model even after adjustment of blood pressure, hypertension, cardiovascular disease, diabetes, and amount of daily intake for caffeine-containing foods such as tea and chocolate, coffee consumers with 1 cup per day (HR, 0.76; 95% confidence interval, 0.63-0.92) and ≥2 cups per day (HR, 0.80; 95% confidence interval, 0.65-0.98) were associated with a lower risk of chronic kidney disease development than nondrinkers. Time-averaged and time-varying Cox models yielded similar results. The rates of decline in glomerular filtration were lower in daily coffee consumers. Conclusions: Our findings suggest that daily coffee intake is associated with decreased risk of the development of chronic kidney disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1482-1490.e3 |
| Journal | American Journal of Medicine |
| Volume | 131 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2018 Dec |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Effects of Coffee Intake on Incident Chronic Kidney Disease : A Community-Based Prospective Cohort Study. / Jhee, Jong Hyun; Nam, Ki Heon; An, Seong Yeong; Cha, Min Uk; Lee, Misol; Park, Seohyun; Kim, Hyoungnae; Yun, Hae Ryong; Kee, Youn Kyung; Park, Jung Tak; Chang, Tae Ik; Kang, Ea Wha; Yoo, Tae Hyun; Kang, Shin Wook; Han, Seung Hyeok.
In: American Journal of Medicine, Vol. 131, No. 12, 12.2018, p. 1482-1490.e3.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of Coffee Intake on Incident Chronic Kidney Disease
T2 - A Community-Based Prospective Cohort Study
AU - Jhee, Jong Hyun
AU - Nam, Ki Heon
AU - An, Seong Yeong
AU - Cha, Min Uk
AU - Lee, Misol
AU - Park, Seohyun
AU - Kim, Hyoungnae
AU - Yun, Hae Ryong
AU - Kee, Youn Kyung
AU - Park, Jung Tak
AU - Chang, Tae Ik
AU - Kang, Ea Wha
AU - Yoo, Tae Hyun
AU - Kang, Shin Wook
AU - Han, Seung Hyeok
PY - 2018/12
Y1 - 2018/12
N2 - Background: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. Methods: We analyzed 8717 subjects with normal renal function recruited from the Korean Genome and Epidemiology Study (KoGES) cohort. Based on a food frequency questionnaire, coffee consumption was categorized into 5 groups: 0 per week, <1 cup per week, 1-6 cups per week, 1 cup per day, and ≥2 cups per day. The primary outcome was incident chronic kidney disease, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2. Results: The mean age (standard deviation) of study subjects was 52.0 (8.8) years, and 47.8% were male. Among the subjects, 52.8% were daily coffee consumers. During a mean follow-up of 11.3 (range, 5.9-11.5) years, 9.5% of participants developed chronic kidney disease. The incident chronic kidney disease occurred less in daily coffee consumers. Unadjusted hazard ratios (HRs) was significantly lower in daily coffee consumers. In multivariable Cox model even after adjustment of blood pressure, hypertension, cardiovascular disease, diabetes, and amount of daily intake for caffeine-containing foods such as tea and chocolate, coffee consumers with 1 cup per day (HR, 0.76; 95% confidence interval, 0.63-0.92) and ≥2 cups per day (HR, 0.80; 95% confidence interval, 0.65-0.98) were associated with a lower risk of chronic kidney disease development than nondrinkers. Time-averaged and time-varying Cox models yielded similar results. The rates of decline in glomerular filtration were lower in daily coffee consumers. Conclusions: Our findings suggest that daily coffee intake is associated with decreased risk of the development of chronic kidney disease.
AB - Background: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. Methods: We analyzed 8717 subjects with normal renal function recruited from the Korean Genome and Epidemiology Study (KoGES) cohort. Based on a food frequency questionnaire, coffee consumption was categorized into 5 groups: 0 per week, <1 cup per week, 1-6 cups per week, 1 cup per day, and ≥2 cups per day. The primary outcome was incident chronic kidney disease, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2. Results: The mean age (standard deviation) of study subjects was 52.0 (8.8) years, and 47.8% were male. Among the subjects, 52.8% were daily coffee consumers. During a mean follow-up of 11.3 (range, 5.9-11.5) years, 9.5% of participants developed chronic kidney disease. The incident chronic kidney disease occurred less in daily coffee consumers. Unadjusted hazard ratios (HRs) was significantly lower in daily coffee consumers. In multivariable Cox model even after adjustment of blood pressure, hypertension, cardiovascular disease, diabetes, and amount of daily intake for caffeine-containing foods such as tea and chocolate, coffee consumers with 1 cup per day (HR, 0.76; 95% confidence interval, 0.63-0.92) and ≥2 cups per day (HR, 0.80; 95% confidence interval, 0.65-0.98) were associated with a lower risk of chronic kidney disease development than nondrinkers. Time-averaged and time-varying Cox models yielded similar results. The rates of decline in glomerular filtration were lower in daily coffee consumers. Conclusions: Our findings suggest that daily coffee intake is associated with decreased risk of the development of chronic kidney disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=85049104750&partnerID=8YFLogxK
U2 - 10.1016/j.amjmed.2018.05.021
DO - 10.1016/j.amjmed.2018.05.021
M3 - Article
C2 - 29906428
AN - SCOPUS:85049104750
VL - 131
SP - 1482-1490.e3
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 12
ER -