Continuous positive airway pressure (CPAP) therapy may decrease left ventricular (LV) loads and improve myocardial oxygenation. In this study, we investigated the effect of CPAP on LV diastolic function compared with sham treatment in patients with severe obstructive sleep apnoea (OSA). This 3-month prospective single-centre randomised sham-controlled trial analysed 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3 months. The main investigator and patients were masked to the trial randomisation. The primary endpoint was change of early diastolic mitral annular (e) velocity over the 3-month period. Secondary end-points were pulse wave velocity (PWV), 24-h ambulatory blood pressure (BP) and variables of ventricular-vascular coupling at 3 months. After 3 months of follow-up, CPAP treatment significantly increased the e velocity, and was greater than the sham treatment (0.65±1.70 versus -0.61±1.85 cms-1, p=0.014). The PWV, 24-h mean diastolic BP, night-time diastolic BP, arterial elastance index and ventricular-vascular coupling index after 3 months of follow-up decreased significantly in the CPAP group. In patients with severe OSA, CPAP treatment for 3 months improved LV diastolic function more than sham treatment, and was accompanied by improvements in arterial stiffness and ventricular-vascular coupling.
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Support statement: This study was supported by a Yuhan research grant and a faculty research grant at Yonsei University. Funding information for this article has been deposited with the Crossref Funder Registry.
Copyright © ERS 2018.
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine