Effects of dietary calcium deficiency on morphological and mechanical characteristics of caudal vertebral bone in living rats

Gon Woo Dae, Yong Ko Chang, Woo Lee Tae, Jin Joo Min, Rin Lee Hye, Sung Kim Han

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the present study, morphological and mechanical characteristics in caudal vertebrae of rats with calcium free diet (CFD) were detected and tracked to investigate the correlation between bone metabolism and calcium deficiency, using micro-computed tomography (micro-CT) and finite element (FE) analysis. Twelve female Sprague Dawley rats (12 weeks old) were randomly divided into two groups, CFD and normal groups. The rats were observed from 0 week (just before starting CFD) to 8 weeks. Structural parameters, bone mineral density (BMD) and effective modulus were measured and calculated. There was more significant age-related decrease of BV/TV, Tb.Th and Tb.N in CFD group than in normal group, whereas more significant increase of Tb.Sp and SMI was found in CFD group than in normal group. In CFD group, BMD of trabecular bones decreased. However, there was no change in that of cortical bones from 0 week (just before starting CFD) to 8 weeks. In the simulated compression test using FE models, the structural modulus of CFD group was smaller than that of normal group. In conclusion, CFD led to bone loss and decreased bone strength in the rat caudal bones.

Original languageEnglish
Title of host publicationProceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006
Pages44-49
Number of pages6
Publication statusPublished - 2006 Dec 1
Event4th IASTED International Conference on Biomechanics, BioMech 2006 - Palma de Mallorca, Spain
Duration: 2006 Aug 282006 Aug 29

Other

Other4th IASTED International Conference on Biomechanics, BioMech 2006
CountrySpain
CityPalma de Mallorca
Period06/8/2806/8/29

Fingerprint

Dietary Calcium
Nutrition
Rats
Calcium
Bone
Bone and Bones
Diet
Bone Density
Minerals
Finite Element Analysis
Structural Models
Metabolism
Tomography
Sprague Dawley Rats
Spine
Finite element method

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Mechanical Engineering

Cite this

Dae, G. W., Chang, Y. K., Tae, W. L., Min, J. J., Hye, R. L., & Han, S. K. (2006). Effects of dietary calcium deficiency on morphological and mechanical characteristics of caudal vertebral bone in living rats. In Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006 (pp. 44-49)
Dae, Gon Woo ; Chang, Yong Ko ; Tae, Woo Lee ; Min, Jin Joo ; Hye, Rin Lee ; Han, Sung Kim. / Effects of dietary calcium deficiency on morphological and mechanical characteristics of caudal vertebral bone in living rats. Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006. 2006. pp. 44-49
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abstract = "In the present study, morphological and mechanical characteristics in caudal vertebrae of rats with calcium free diet (CFD) were detected and tracked to investigate the correlation between bone metabolism and calcium deficiency, using micro-computed tomography (micro-CT) and finite element (FE) analysis. Twelve female Sprague Dawley rats (12 weeks old) were randomly divided into two groups, CFD and normal groups. The rats were observed from 0 week (just before starting CFD) to 8 weeks. Structural parameters, bone mineral density (BMD) and effective modulus were measured and calculated. There was more significant age-related decrease of BV/TV, Tb.Th and Tb.N in CFD group than in normal group, whereas more significant increase of Tb.Sp and SMI was found in CFD group than in normal group. In CFD group, BMD of trabecular bones decreased. However, there was no change in that of cortical bones from 0 week (just before starting CFD) to 8 weeks. In the simulated compression test using FE models, the structural modulus of CFD group was smaller than that of normal group. In conclusion, CFD led to bone loss and decreased bone strength in the rat caudal bones.",
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Dae, GW, Chang, YK, Tae, WL, Min, JJ, Hye, RL & Han, SK 2006, Effects of dietary calcium deficiency on morphological and mechanical characteristics of caudal vertebral bone in living rats. in Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006. pp. 44-49, 4th IASTED International Conference on Biomechanics, BioMech 2006, Palma de Mallorca, Spain, 06/8/28.

Effects of dietary calcium deficiency on morphological and mechanical characteristics of caudal vertebral bone in living rats. / Dae, Gon Woo; Chang, Yong Ko; Tae, Woo Lee; Min, Jin Joo; Hye, Rin Lee; Han, Sung Kim.

Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006. 2006. p. 44-49.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Dae GW, Chang YK, Tae WL, Min JJ, Hye RL, Han SK. Effects of dietary calcium deficiency on morphological and mechanical characteristics of caudal vertebral bone in living rats. In Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006. 2006. p. 44-49