Effects of education on aging-related cortical thinning among cognitively normal individuals

Jun Pyo Kim, Sang Won Seo, Hee Young Shin, Byoung Seok Ye, Jin Ju Yang, Changsoo Kim, Mira Kang, Seun Jeon, Hee Jin Kim, Hanna Cho, Jung Hyun Kim, Jong Min Lee, Sung Tae Kim, Duk L. Na, Eliseo Guallar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.

Original languageEnglish
Pages (from-to)806-812
Number of pages7
JournalNeurology
Volume85
Issue number9
DOIs
Publication statusPublished - 2015 Sep 1

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Education
Occipital Lobe
Parietal Lobe
Gyrus Cinguli
Motor Cortex
Linear Models
Regression Analysis
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Kim, J. P., Seo, S. W., Shin, H. Y., Ye, B. S., Yang, J. J., Kim, C., ... Guallar, E. (2015). Effects of education on aging-related cortical thinning among cognitively normal individuals. Neurology, 85(9), 806-812. https://doi.org/10.1212/WNL.0000000000001884
Kim, Jun Pyo ; Seo, Sang Won ; Shin, Hee Young ; Ye, Byoung Seok ; Yang, Jin Ju ; Kim, Changsoo ; Kang, Mira ; Jeon, Seun ; Kim, Hee Jin ; Cho, Hanna ; Kim, Jung Hyun ; Lee, Jong Min ; Kim, Sung Tae ; Na, Duk L. ; Guallar, Eliseo. / Effects of education on aging-related cortical thinning among cognitively normal individuals. In: Neurology. 2015 ; Vol. 85, No. 9. pp. 806-812.
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abstract = "Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.",
author = "Kim, {Jun Pyo} and Seo, {Sang Won} and Shin, {Hee Young} and Ye, {Byoung Seok} and Yang, {Jin Ju} and Changsoo Kim and Mira Kang and Seun Jeon and Kim, {Hee Jin} and Hanna Cho and Kim, {Jung Hyun} and Lee, {Jong Min} and Kim, {Sung Tae} and Na, {Duk L.} and Eliseo Guallar",
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Kim, JP, Seo, SW, Shin, HY, Ye, BS, Yang, JJ, Kim, C, Kang, M, Jeon, S, Kim, HJ, Cho, H, Kim, JH, Lee, JM, Kim, ST, Na, DL & Guallar, E 2015, 'Effects of education on aging-related cortical thinning among cognitively normal individuals', Neurology, vol. 85, no. 9, pp. 806-812. https://doi.org/10.1212/WNL.0000000000001884

Effects of education on aging-related cortical thinning among cognitively normal individuals. / Kim, Jun Pyo; Seo, Sang Won; Shin, Hee Young; Ye, Byoung Seok; Yang, Jin Ju; Kim, Changsoo; Kang, Mira; Jeon, Seun; Kim, Hee Jin; Cho, Hanna; Kim, Jung Hyun; Lee, Jong Min; Kim, Sung Tae; Na, Duk L.; Guallar, Eliseo.

In: Neurology, Vol. 85, No. 9, 01.09.2015, p. 806-812.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of education on aging-related cortical thinning among cognitively normal individuals

AU - Kim, Jun Pyo

AU - Seo, Sang Won

AU - Shin, Hee Young

AU - Ye, Byoung Seok

AU - Yang, Jin Ju

AU - Kim, Changsoo

AU - Kang, Mira

AU - Jeon, Seun

AU - Kim, Hee Jin

AU - Cho, Hanna

AU - Kim, Jung Hyun

AU - Lee, Jong Min

AU - Kim, Sung Tae

AU - Na, Duk L.

AU - Guallar, Eliseo

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.

AB - Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.

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