Abstract
Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 806-812 |
| Number of pages | 7 |
| Journal | Neurology |
| Volume | 85 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2015 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Clinical Neurology
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Effects of education on aging-related cortical thinning among cognitively normal individuals. / Kim, Jun Pyo; Seo, Sang Won; Shin, Hee Young; Ye, Byoung Seok; Yang, Jin Ju; Kim, Changsoo; Kang, Mira; Jeon, Seun; Kim, Hee Jin; Cho, Hanna; Kim, Jung Hyun; Lee, Jong Min; Kim, Sung Tae; Na, Duk L.; Guallar, Eliseo.
In: Neurology, Vol. 85, No. 9, 01.09.2015, p. 806-812.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of education on aging-related cortical thinning among cognitively normal individuals
AU - Kim, Jun Pyo
AU - Seo, Sang Won
AU - Shin, Hee Young
AU - Ye, Byoung Seok
AU - Yang, Jin Ju
AU - Kim, Changsoo
AU - Kang, Mira
AU - Jeon, Seun
AU - Kim, Hee Jin
AU - Cho, Hanna
AU - Kim, Jung Hyun
AU - Lee, Jong Min
AU - Kim, Sung Tae
AU - Na, Duk L.
AU - Guallar, Eliseo
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.
AB - Objectives: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. Methods: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. Results: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p 0.019). Conclusions: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.
UR - http://www.scopus.com/inward/record.url?scp=84946706612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946706612&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000001884
DO - 10.1212/WNL.0000000000001884
M3 - Article
C2 - 26231257
AN - SCOPUS:84946706612
VL - 85
SP - 806
EP - 812
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 9
ER -