Effects of emollient containing bee venom on atopic dermatitis: A double-blinded, randomized, base-controlled, multicenter study of 136 patients

Chung Eui You, Seok Hoon Moon, Kwang Hoon Lee, Kyu Han Kim, Chun Wook Park, Seong Joon Seo, Sang Hyun Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Atopic dermatitis (AD) is a common, complex disease that follows a chronic relapsing course and significantly affects the quality of life of patients. Skin barrier dysfunction and inflammatory processes induce and aggravate this skin condition. Proper use of an emollient for hydration is a keystone of AD treatment. Bee venom is known to have anti-inflammatory effects and has been widely used in traditional medicine to treat various inflammatory disorders. Objective: To find out the beneficial effect of an emollient containing bee venom in the treatment of patients with AD. Methods: This study included 136 patients with AD who were randomized to receive either an emollient containing bee venom and silk-protein or a vehicle that was identical except for the bee venom for 4 weeks. The patients were instructed to apply the emollient twice daily on their entire body and not to use other medications, including topicals, during the course of the study. The eczema area and severity index (EASI) score, transepidermal water loss, and visual analogue scale (VAS) score of itching were evaluated at the first visit and after 2 and 4 weeks. The investigator global assessment was evaluated at 2 and 4 weeks after the application of emollient containing bee venom or vehicle. Results: Patients applying emollient containing bee venom showed significantly lower EASI score and VAS value compared to patients applying emollient without bee venom. Conclusion: Emollient containing bee venom is a safe and effective option for patients with AD.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalAnnals of Dermatology
Volume28
Issue number5
DOIs
Publication statusPublished - 2016 Oct

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Emollients
Bee Venoms
Atopic Dermatitis
Multicenter Studies
Eczema
Visual Analog Scale
Skin
Silk
Traditional Medicine
Pruritus
Anti-Inflammatory Agents
Quality of Life
Research Personnel
Water

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

You, Chung Eui ; Moon, Seok Hoon ; Lee, Kwang Hoon ; Kim, Kyu Han ; Park, Chun Wook ; Seo, Seong Joon ; Cho, Sang Hyun. / Effects of emollient containing bee venom on atopic dermatitis : A double-blinded, randomized, base-controlled, multicenter study of 136 patients. In: Annals of Dermatology. 2016 ; Vol. 28, No. 5. pp. 593-599.
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abstract = "Background: Atopic dermatitis (AD) is a common, complex disease that follows a chronic relapsing course and significantly affects the quality of life of patients. Skin barrier dysfunction and inflammatory processes induce and aggravate this skin condition. Proper use of an emollient for hydration is a keystone of AD treatment. Bee venom is known to have anti-inflammatory effects and has been widely used in traditional medicine to treat various inflammatory disorders. Objective: To find out the beneficial effect of an emollient containing bee venom in the treatment of patients with AD. Methods: This study included 136 patients with AD who were randomized to receive either an emollient containing bee venom and silk-protein or a vehicle that was identical except for the bee venom for 4 weeks. The patients were instructed to apply the emollient twice daily on their entire body and not to use other medications, including topicals, during the course of the study. The eczema area and severity index (EASI) score, transepidermal water loss, and visual analogue scale (VAS) score of itching were evaluated at the first visit and after 2 and 4 weeks. The investigator global assessment was evaluated at 2 and 4 weeks after the application of emollient containing bee venom or vehicle. Results: Patients applying emollient containing bee venom showed significantly lower EASI score and VAS value compared to patients applying emollient without bee venom. Conclusion: Emollient containing bee venom is a safe and effective option for patients with AD.",
author = "You, {Chung Eui} and Moon, {Seok Hoon} and Lee, {Kwang Hoon} and Kim, {Kyu Han} and Park, {Chun Wook} and Seo, {Seong Joon} and Cho, {Sang Hyun}",
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Effects of emollient containing bee venom on atopic dermatitis : A double-blinded, randomized, base-controlled, multicenter study of 136 patients. / You, Chung Eui; Moon, Seok Hoon; Lee, Kwang Hoon; Kim, Kyu Han; Park, Chun Wook; Seo, Seong Joon; Cho, Sang Hyun.

In: Annals of Dermatology, Vol. 28, No. 5, 10.2016, p. 593-599.

Research output: Contribution to journalArticle

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AU - You, Chung Eui

AU - Moon, Seok Hoon

AU - Lee, Kwang Hoon

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AU - Seo, Seong Joon

AU - Cho, Sang Hyun

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N2 - Background: Atopic dermatitis (AD) is a common, complex disease that follows a chronic relapsing course and significantly affects the quality of life of patients. Skin barrier dysfunction and inflammatory processes induce and aggravate this skin condition. Proper use of an emollient for hydration is a keystone of AD treatment. Bee venom is known to have anti-inflammatory effects and has been widely used in traditional medicine to treat various inflammatory disorders. Objective: To find out the beneficial effect of an emollient containing bee venom in the treatment of patients with AD. Methods: This study included 136 patients with AD who were randomized to receive either an emollient containing bee venom and silk-protein or a vehicle that was identical except for the bee venom for 4 weeks. The patients were instructed to apply the emollient twice daily on their entire body and not to use other medications, including topicals, during the course of the study. The eczema area and severity index (EASI) score, transepidermal water loss, and visual analogue scale (VAS) score of itching were evaluated at the first visit and after 2 and 4 weeks. The investigator global assessment was evaluated at 2 and 4 weeks after the application of emollient containing bee venom or vehicle. Results: Patients applying emollient containing bee venom showed significantly lower EASI score and VAS value compared to patients applying emollient without bee venom. Conclusion: Emollient containing bee venom is a safe and effective option for patients with AD.

AB - Background: Atopic dermatitis (AD) is a common, complex disease that follows a chronic relapsing course and significantly affects the quality of life of patients. Skin barrier dysfunction and inflammatory processes induce and aggravate this skin condition. Proper use of an emollient for hydration is a keystone of AD treatment. Bee venom is known to have anti-inflammatory effects and has been widely used in traditional medicine to treat various inflammatory disorders. Objective: To find out the beneficial effect of an emollient containing bee venom in the treatment of patients with AD. Methods: This study included 136 patients with AD who were randomized to receive either an emollient containing bee venom and silk-protein or a vehicle that was identical except for the bee venom for 4 weeks. The patients were instructed to apply the emollient twice daily on their entire body and not to use other medications, including topicals, during the course of the study. The eczema area and severity index (EASI) score, transepidermal water loss, and visual analogue scale (VAS) score of itching were evaluated at the first visit and after 2 and 4 weeks. The investigator global assessment was evaluated at 2 and 4 weeks after the application of emollient containing bee venom or vehicle. Results: Patients applying emollient containing bee venom showed significantly lower EASI score and VAS value compared to patients applying emollient without bee venom. Conclusion: Emollient containing bee venom is a safe and effective option for patients with AD.

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