Effects of GM-CSF on the neural progenitor cells

Jin Kyun Kim, Byung Hyun Choi, Hyung Chun Park, So Ra Park, Young Soo Kim, Seung Hwan Yoon, Hyun Seon Park, Eun Young Kim, Yoon Ha

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36 Citations (Scopus)

Abstract

Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow. We now report that GM-CSF receptors expressed on neural progenitor cells and can mediate a biological response in cells to treat with GM-CSF treated neural progenitor cells exhibited a proliferative response and a marked decrease in terminal differentiation to mature neuron or astrocytes. GM-CSF treatment also suppressed neural progenitor cell apoptosis. These findings suggest that GM-CSF can stimulate the proliferation and inhibit the apoptosis of neural progenitor cells to expand the progenitor population, and that GM-CSF has a potential role in neural development or repair.

Original languageEnglish
Pages (from-to)2161-2165
Number of pages5
JournalNeuroReport
Volume15
Issue number14
DOIs
Publication statusPublished - 2004 Oct 5

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Kim, J. K., Choi, B. H., Park, H. C., Park, S. R., Kim, Y. S., Yoon, S. H., Park, H. S., Kim, E. Y., & Ha, Y. (2004). Effects of GM-CSF on the neural progenitor cells. NeuroReport, 15(14), 2161-2165. https://doi.org/10.1097/00001756-200410050-00003