Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

Bing Chun Yan; Joon Ha Park; Ji Hyeon Ahn; In Hye Kim; Jae Chul Lee; Ki Yeon Yoo; Jung Hoon Choi; In Koo Hwang; Jun Hwi Cho; Young Guen Kwon; Young Myeong Kim; Choong Hyun Lee; Moo Ho Won

doi:10.1007/s11064-014-1450-8

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

Bing Chun Yan, Joon Ha Park, Ji Hyeon Ahn, In Hye Kim, Jae Chul Lee, Ki Yeon Yoo, Jung Hoon Choi, In Koo Hwang, Jun Hwi Cho, Young Guen Kwon, Young Myeong Kim, Choong Hyun Lee, Moo Ho Won

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21 Citations (Scopus)

Abstract

In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

Original language	English
Pages (from-to)	2465-2478
Number of pages	14
Journal	Neurochemical Research
Volume	39
Issue number	12
DOIs	https://doi.org/10.1007/s11064-014-1450-8
Publication status	Published - 2014 Nov 25

Bibliographical note

Funding Information:
Acknowledgments The authors would like to thank Mr. Seung Uk Lee for his technical help in this study. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2014R1A2A2A01005307), and by the National Research Foundation of Korea (NRF-2013M3A9B6046563), which was funded by the Ministry of Science, ICT, and Future Planning.

Publisher Copyright:
© 2014, Springer Science+Business Media New York.

All Science Journal Classification (ASJC) codes

Biochemistry
Cellular and Molecular Neuroscience

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10.1007/s11064-014-1450-8

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Yan, B. C., Park, J. H., Ahn, J. H., Kim, I. H., Lee, J. C., Yoo, K. Y., Choi, J. H., Hwang, I. K., Cho, J. H., Kwon, Y. G., Kim, Y. M., Lee, C. H., & Won, M. H. (2014). Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia. Neurochemical Research, 39(12), 2465-2478. https://doi.org/10.1007/s11064-014-1450-8

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title = "Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia",

abstract = "In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.",

author = "Yan, {Bing Chun} and Park, {Joon Ha} and Ahn, {Ji Hyeon} and Kim, {In Hye} and Lee, {Jae Chul} and Yoo, {Ki Yeon} and Choi, {Jung Hoon} and Hwang, {In Koo} and Cho, {Jun Hwi} and Kwon, {Young Guen} and Kim, {Young Myeong} and Lee, {Choong Hyun} and Won, {Moo Ho}",

note = "Funding Information: Acknowledgments The authors would like to thank Mr. Seung Uk Lee for his technical help in this study. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2014R1A2A2A01005307), and by the National Research Foundation of Korea (NRF-2013M3A9B6046563), which was funded by the Ministry of Science, ICT, and Future Planning. Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",

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doi = "10.1007/s11064-014-1450-8",

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Yan, BC, Park, JH, Ahn, JH, Kim, IH, Lee, JC, Yoo, KY, Choi, JH, Hwang, IK, Cho, JH, Kwon, YG, Kim, YM, Lee, CH & Won, MH 2014, 'Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia', Neurochemical Research, vol. 39, no. 12, pp. 2465-2478. https://doi.org/10.1007/s11064-014-1450-8

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T1 - Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

AU - Yan, Bing Chun

AU - Park, Joon Ha

AU - Ahn, Ji Hyeon

AU - Kim, In Hye

AU - Lee, Jae Chul

AU - Yoo, Ki Yeon

AU - Choi, Jung Hoon

AU - Hwang, In Koo

AU - Cho, Jun Hwi

AU - Kwon, Young Guen

AU - Kim, Young Myeong

AU - Lee, Choong Hyun

AU - Won, Moo Ho

N1 - Funding Information: Acknowledgments The authors would like to thank Mr. Seung Uk Lee for his technical help in this study. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2014R1A2A2A01005307), and by the National Research Foundation of Korea (NRF-2013M3A9B6046563), which was funded by the Ministry of Science, ICT, and Future Planning. Publisher Copyright: © 2014, Springer Science+Business Media New York.

PY - 2014/11/25

Y1 - 2014/11/25

N2 - In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

AB - In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

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Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

Abstract

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