Abstract
In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 2465-2478 |
| Number of pages | 14 |
| Journal | Neurochemical Research |
| Volume | 39 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2014 Nov 25 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Cellular and Molecular Neuroscience
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Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia. / Yan, Bing Chun; Park, Joon Ha; Ahn, Ji Hyeon; Kim, In Hye; Lee, Jae Chul; Yoo, Ki Yeon; Choi, Jung Hoon; Hwang, In Koo; Cho, Jun Hwi; Kwon, Young Guen; Kim, Young Myeong; Lee, Choong Hyun; Won, Moo Ho.
In: Neurochemical Research, Vol. 39, No. 12, 25.11.2014, p. 2465-2478.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia
AU - Yan, Bing Chun
AU - Park, Joon Ha
AU - Ahn, Ji Hyeon
AU - Kim, In Hye
AU - Lee, Jae Chul
AU - Yoo, Ki Yeon
AU - Choi, Jung Hoon
AU - Hwang, In Koo
AU - Cho, Jun Hwi
AU - Kwon, Young Guen
AU - Kim, Young Myeong
AU - Lee, Choong Hyun
AU - Won, Moo Ho
PY - 2014/11/25
Y1 - 2014/11/25
N2 - In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.
AB - In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.
UR - http://www.scopus.com/inward/record.url?scp=84912570143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912570143&partnerID=8YFLogxK
U2 - 10.1007/s11064-014-1450-8
DO - 10.1007/s11064-014-1450-8
M3 - Article
C2 - 25307112
AN - SCOPUS:84912570143
VL - 39
SP - 2465
EP - 2478
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 12
ER -