Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

Bing Chun Yan, Joon Ha Park, Ji Hyeon Ahn, In Hye Kim, Jae Chul Lee, Ki Yeon Yoo, Jung Hoon Choi, In Koo Hwang, Jun Hwi Cho, Young Guen Kwon, Young Myeong Kim, Choong Hyun Lee, Moo Ho Won

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

Original languageEnglish
Pages (from-to)2465-2478
Number of pages14
JournalNeurochemical Research
Volume39
Issue number12
DOIs
Publication statusPublished - 2014 Nov 25

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Gliosis
Oxidative stress
Transient Ischemic Attack
High Fat Diet
Nutrition
Gerbillinae
Hippocampus
Oxidative Stress
Hippocampal CA1 Region
Fats
Ischemia
Reperfusion
Neuroglia
Cytokines
Diet
Chemical activation
Interleukin-4
Interleukin-2
Anti-Inflammatory Agents
Antioxidants

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Yan, Bing Chun ; Park, Joon Ha ; Ahn, Ji Hyeon ; Kim, In Hye ; Lee, Jae Chul ; Yoo, Ki Yeon ; Choi, Jung Hoon ; Hwang, In Koo ; Cho, Jun Hwi ; Kwon, Young Guen ; Kim, Young Myeong ; Lee, Choong Hyun ; Won, Moo Ho. / Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia. In: Neurochemical Research. 2014 ; Vol. 39, No. 12. pp. 2465-2478.
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abstract = "In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.",
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Yan, BC, Park, JH, Ahn, JH, Kim, IH, Lee, JC, Yoo, KY, Choi, JH, Hwang, IK, Cho, JH, Kwon, YG, Kim, YM, Lee, CH & Won, MH 2014, 'Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia', Neurochemical Research, vol. 39, no. 12, pp. 2465-2478. https://doi.org/10.1007/s11064-014-1450-8

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia. / Yan, Bing Chun; Park, Joon Ha; Ahn, Ji Hyeon; Kim, In Hye; Lee, Jae Chul; Yoo, Ki Yeon; Choi, Jung Hoon; Hwang, In Koo; Cho, Jun Hwi; Kwon, Young Guen; Kim, Young Myeong; Lee, Choong Hyun; Won, Moo Ho.

In: Neurochemical Research, Vol. 39, No. 12, 25.11.2014, p. 2465-2478.

Research output: Contribution to journalArticle

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T1 - Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

AU - Yan, Bing Chun

AU - Park, Joon Ha

AU - Ahn, Ji Hyeon

AU - Kim, In Hye

AU - Lee, Jae Chul

AU - Yoo, Ki Yeon

AU - Choi, Jung Hoon

AU - Hwang, In Koo

AU - Cho, Jun Hwi

AU - Kwon, Young Guen

AU - Kim, Young Myeong

AU - Lee, Choong Hyun

AU - Won, Moo Ho

PY - 2014/11/25

Y1 - 2014/11/25

N2 - In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

AB - In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

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