Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy

Jung Min Lee, JaeHee Cheon, Jae Jun Park, Chang Mo Moon, Eun Soo Kim, Tae Il Kim, Won Ho Kim

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background/Aims: Colonoscopy has a significant miss rate for colorectal polyp screening. The present study hypothesized that reduced colonic spasm with antispasmodic agents might yield a better visual field to result in enhanced polyp detection rate. Methodology: In a prospective, randomized, double-blind study design, muscle spasm was recorded during insertion and withdrawal during routine colonoscopy, and the number of polyps detected were compared between two groups of 58 patients characterized with either hyosine N-butyl bromide (Hyosine group) or placebo (Placebo group) injected at reaching the cecum. Results: The number of patients with decrease in spasm score of 0, 1, and 2 between insertion and withdrawal were 5 (8.6%), 31 (53.4%), and 22 (37.9%) in the Hyosine group, and 10 (17.2%), 46 (79.3%), and 2 (3.4%) in the Placebo group, respectively (p<.001). In patients with spasm score ≥3 during insertion, more polyps per patient were likely to be detected in the Hyoscine group than the Placebo group (1.21±2.23 vs. 0.41±0.91; p=0.060). Conclusions: Our study suggests that hyosine might increase the detection rate of polyps in patients with moderate to marked degree of colonic spasm during colonoscope insertion. Further large scale studies are needed to validate our observations.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalHepato-gastroenterology
Volume57
Issue number97
Publication statusPublished - 2010 Jan 1

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Spasm
Colonoscopy
Polyps
Placebos
Colonoscopes
Parasympatholytics
Scopolamine Hydrobromide
Cecum
Visual Fields
Double-Blind Method
butyl bromide

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Lee, J. M., Cheon, J., Park, J. J., Moon, C. M., Kim, E. S., Kim, T. I., & Kim, W. H. (2010). Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy. Hepato-gastroenterology, 57(97), 90-94.
Lee, Jung Min ; Cheon, JaeHee ; Park, Jae Jun ; Moon, Chang Mo ; Kim, Eun Soo ; Kim, Tae Il ; Kim, Won Ho. / Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy. In: Hepato-gastroenterology. 2010 ; Vol. 57, No. 97. pp. 90-94.
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Lee, JM, Cheon, J, Park, JJ, Moon, CM, Kim, ES, Kim, TI & Kim, WH 2010, 'Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy', Hepato-gastroenterology, vol. 57, no. 97, pp. 90-94.

Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy. / Lee, Jung Min; Cheon, JaeHee; Park, Jae Jun; Moon, Chang Mo; Kim, Eun Soo; Kim, Tae Il; Kim, Won Ho.

In: Hepato-gastroenterology, Vol. 57, No. 97, 01.01.2010, p. 90-94.

Research output: Contribution to journalArticle

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T1 - Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy

AU - Lee, Jung Min

AU - Cheon, JaeHee

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AU - Kim, Tae Il

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Lee JM, Cheon J, Park JJ, Moon CM, Kim ES, Kim TI et al. Effects of hyosine N-butyl bromide on the detection of polyps during colonoscopy. Hepato-gastroenterology. 2010 Jan 1;57(97):90-94.