Effects of Korean red ginseng (Panax ginseng), urushiol (Rhus vernicifera stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease

Chang Seok Bang, So Hyung Hong, Ki Tae Suk, Jin Bong Kim, Sang Hak Han, Hotaik Sung, Eun Ji Kim, Myoung Jo Kim, Moon Young Kim, Soon Koo Baik, Dong Joon Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin- 1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalJournal of Ginseng Research
Volume38
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

mannosulfan
Rhus
Lactobacillus rhamnosus
Lactobacillus acidophilus
Alcoholic Liver Diseases
Panax
Probiotics
Liver
Alcohols
Toll-Like Receptor 4
Nutrition
Antigen-antibody reactions
Tissue
Diet
Histology
urushiol
Liver Function Tests
Interleukin-1
Inbred C57BL Mouse
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine

Cite this

Bang, Chang Seok ; Hong, So Hyung ; Suk, Ki Tae ; Kim, Jin Bong ; Han, Sang Hak ; Sung, Hotaik ; Kim, Eun Ji ; Kim, Myoung Jo ; Kim, Moon Young ; Baik, Soon Koo ; Kim, Dong Joon. / Effects of Korean red ginseng (Panax ginseng), urushiol (Rhus vernicifera stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease. In: Journal of Ginseng Research. 2014 ; Vol. 38, No. 3. pp. 167-172.
@article{1243cbe0f3cd4881bdc583ccb99efbda,
title = "Effects of Korean red ginseng (Panax ginseng), urushiol (Rhus vernicifera stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease",
abstract = "Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10{\%} alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin- 1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.",
author = "Bang, {Chang Seok} and Hong, {So Hyung} and Suk, {Ki Tae} and Kim, {Jin Bong} and Han, {Sang Hak} and Hotaik Sung and Kim, {Eun Ji} and Kim, {Myoung Jo} and Kim, {Moon Young} and Baik, {Soon Koo} and Kim, {Dong Joon}",
year = "2014",
doi = "10.1016/j.jgr.2014.04.002",
language = "English",
volume = "38",
pages = "167--172",
journal = "Journal of Ginseng Research",
issn = "1226-8453",
publisher = "The Korean Society of Ginseng",
number = "3",

}

Effects of Korean red ginseng (Panax ginseng), urushiol (Rhus vernicifera stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease. / Bang, Chang Seok; Hong, So Hyung; Suk, Ki Tae; Kim, Jin Bong; Han, Sang Hak; Sung, Hotaik; Kim, Eun Ji; Kim, Myoung Jo; Kim, Moon Young; Baik, Soon Koo; Kim, Dong Joon.

In: Journal of Ginseng Research, Vol. 38, No. 3, 2014, p. 167-172.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Korean red ginseng (Panax ginseng), urushiol (Rhus vernicifera stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease

AU - Bang, Chang Seok

AU - Hong, So Hyung

AU - Suk, Ki Tae

AU - Kim, Jin Bong

AU - Han, Sang Hak

AU - Sung, Hotaik

AU - Kim, Eun Ji

AU - Kim, Myoung Jo

AU - Kim, Moon Young

AU - Baik, Soon Koo

AU - Kim, Dong Joon

PY - 2014

Y1 - 2014

N2 - Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin- 1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.

AB - Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin- 1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.

UR - http://www.scopus.com/inward/record.url?scp=84904868188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904868188&partnerID=8YFLogxK

U2 - 10.1016/j.jgr.2014.04.002

DO - 10.1016/j.jgr.2014.04.002

M3 - Article

AN - SCOPUS:84904868188

VL - 38

SP - 167

EP - 172

JO - Journal of Ginseng Research

JF - Journal of Ginseng Research

SN - 1226-8453

IS - 3

ER -