Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction

Sung Woo Kang, Seun Jeon, Han Soo Yoo, Seok Jong Chung, Phil Hyu Lee, Young H. Sohn, Mijin Yun, Alan C. Evans, Byoung Seok Ye

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Abstract

ObjectivesTo investigate the independent and interaction effects of Alzheimer disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy.MethodsWe consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-florbetaben PET and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment [MCI] and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models.ResultsCompared to the controls, patients in the pure ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporoparietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test.ConclusionsConcomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.

Original languageEnglish
Pages (from-to)E2015-E2026
JournalNeurology
Volume92
Issue number17
DOIs
Publication statusPublished - 2019 Apr 23

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Lewy Body Disease
Atrophy
Alzheimer Disease
Brain
Dementia
Cognitive Dysfunction
Nortropanes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Kang, S. W., Jeon, S., Yoo, H. S., Chung, S. J., Lee, P. H., Sohn, Y. H., ... Ye, B. S. (2019). Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction. Neurology, 92(17), E2015-E2026. https://doi.org/10.1212/WNL.0000000000007373
Kang, Sung Woo ; Jeon, Seun ; Yoo, Han Soo ; Chung, Seok Jong ; Lee, Phil Hyu ; Sohn, Young H. ; Yun, Mijin ; Evans, Alan C. ; Ye, Byoung Seok. / Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction. In: Neurology. 2019 ; Vol. 92, No. 17. pp. E2015-E2026.
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abstract = "ObjectivesTo investigate the independent and interaction effects of Alzheimer disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy.MethodsWe consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-florbetaben PET and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment [MCI] and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models.ResultsCompared to the controls, patients in the pure ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporoparietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test.ConclusionsConcomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.",
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Kang, SW, Jeon, S, Yoo, HS, Chung, SJ, Lee, PH, Sohn, YH, Yun, M, Evans, AC & Ye, BS 2019, 'Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction', Neurology, vol. 92, no. 17, pp. E2015-E2026. https://doi.org/10.1212/WNL.0000000000007373

Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction. / Kang, Sung Woo; Jeon, Seun; Yoo, Han Soo; Chung, Seok Jong; Lee, Phil Hyu; Sohn, Young H.; Yun, Mijin; Evans, Alan C.; Ye, Byoung Seok.

In: Neurology, Vol. 92, No. 17, 23.04.2019, p. E2015-E2026.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction

AU - Kang, Sung Woo

AU - Jeon, Seun

AU - Yoo, Han Soo

AU - Chung, Seok Jong

AU - Lee, Phil Hyu

AU - Sohn, Young H.

AU - Yun, Mijin

AU - Evans, Alan C.

AU - Ye, Byoung Seok

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Y1 - 2019/4/23

N2 - ObjectivesTo investigate the independent and interaction effects of Alzheimer disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy.MethodsWe consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-florbetaben PET and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment [MCI] and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models.ResultsCompared to the controls, patients in the pure ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporoparietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test.ConclusionsConcomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.

AB - ObjectivesTo investigate the independent and interaction effects of Alzheimer disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy.MethodsWe consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-florbetaben PET and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment [MCI] and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models.ResultsCompared to the controls, patients in the pure ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporoparietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test.ConclusionsConcomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.

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