Effects of long-acting somatostatin analogue (Sandostatin) on manifest diabetic ketoacidosis

Yong Seok Yun, Hyun Chul Lee, Chong Seok Park, Kyung Hee Chang, Chae Hwa Cho, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Kap Bum Huh

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Abstract

Insulin deficiency and counterregulatory hormone excess are the basic process in the development of diabetic ketoacidosis (DKA). Somatostatin, which suppresses the secretion of glucagon and growth hormone, has been known to attenuate the rate of gluconeogesis and ketogenesis in insulin-dependent diabetes mellitus patients. However, the therapeutic efficacy of somatostatin has not been approved to be practical in the treatment of manifest DKA. To examine the additive effect of octreotide, the synthetic long-acting somatostatin analogue SMS 201-995, to conventional treatment of manifest DKA, we compared the correction time of acidosis, ketonuria, and hyperglycemia of patients treated with an intravenous infusion of low-dose insulin (4 units per hour) plus subcutaneous injection of octreotide (50 μg every 6 hours) by low-dose insulin alone. The correction time for hyperglycemia and acidosis did not show any difference between groups (p = 0.089, p = 0.82). However, the time for disappearance of ketonuria of the octreotide-treated group (38.0 ± 32.0 h) was reduced significantly compared to other group (68.3 ± 26.0 h) (p = 0.048). These results indicated that the addition of octreotide to conventional treatment of DKA might improve the correction of ketosis, but would not allow more rapid control of acidosis and hyperglycemia in manifest DKA. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalJournal of Diabetes and its Complications
Volume13
Issue number5-6
DOIs
Publication statusPublished - 1999 Sep

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Yun, Y. S., Lee, H. C., Park, C. S., Chang, K. H., Cho, C. H., Song, Y. D., Lim, S. K., Kim, K. R., & Huh, K. B. (1999). Effects of long-acting somatostatin analogue (Sandostatin) on manifest diabetic ketoacidosis. Journal of Diabetes and its Complications, 13(5-6), 288-292. https://doi.org/10.1016/S1056-8727(99)00059-8