Both the methanolic extract and its fractions (0.01 mg/ml) from Litsea cubeba bark were found to inhibit NO and PGE2 production in LPS-activated RAW264.7 macrophages without significant cytotoxicity at less than 0.01 mg/ml concentration. Moreover, L. cubeba bark extract and its fractions significantly decreased the activity of myeloperoxidase catalyzing oxidation of chloride to HOCl and O2- production was reduced by methanol extract (0.05 mg/ml), chloroform fraction (0.025-0.05 mg/ml) and butanol fraction (0.005 mg/ml). These findings suggest that L. cubeba is beneficial for inflammatory conditions and may contain compound(s) with anti-inflammatory properties.
Bibliographical noteFunding Information:
The work was supported by the National Research Lab program through Functional Biopolymer Lab at Yonsei University (2000-N-NL-01-C-299) and the Korea Research Foundation Grant (KRF-2002-037-F00013).
All Science Journal Classification (ASJC) codes
- Drug Discovery