Effects of methanolic extract and fractions from Litsea cubeba bark on the production of inflammatory mediators in RAW264.7 cells

Eun Mi Choi, Jae Kwan Hwang

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30 Citations (Scopus)

Abstract

Both the methanolic extract and its fractions (0.01 mg/ml) from Litsea cubeba bark were found to inhibit NO and PGE2 production in LPS-activated RAW264.7 macrophages without significant cytotoxicity at less than 0.01 mg/ml concentration. Moreover, L. cubeba bark extract and its fractions significantly decreased the activity of myeloperoxidase catalyzing oxidation of chloride to HOCl and O2- production was reduced by methanol extract (0.05 mg/ml), chloroform fraction (0.025-0.05 mg/ml) and butanol fraction (0.005 mg/ml). These findings suggest that L. cubeba is beneficial for inflammatory conditions and may contain compound(s) with anti-inflammatory properties.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalFitoterapia
Volume75
Issue number2
DOIs
Publication statusPublished - 2004 Mar 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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