Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers

Chang Gon Kim, Joong Bae Ahn, Minkyu Jung, Seung Hoon Beom, Chan Kim, Joo Hoon Kim, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Nam Kyu Kim, Byung Soh Min, Hoguen Kim, Woong Sub Koom, Sang Joon Shin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. Results: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. Conclusions: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalBritish journal of cancer
Volume115
Issue number1
DOIs
Publication statusPublished - 2016 Jun 28

Fingerprint

Microsatellite Instability
Colorectal Neoplasms
Recurrence
Disease-Free Survival
N-methylsuccinimide
Neoplasm Metastasis
Survival
Microsatellite Repeats
Colonic Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, C. G., Ahn, J. B., Jung, M., Beom, S. H., Kim, C., Kim, J. H., ... Shin, S. J. (2016). Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers. British journal of cancer, 115(1), 25-33. https://doi.org/10.1038/bjc.2016.161
Kim, Chang Gon ; Ahn, Joong Bae ; Jung, Minkyu ; Beom, Seung Hoon ; Kim, Chan ; Kim, Joo Hoon ; Heo, Su Jin ; Park, Hyung Soon ; Kim, Jee Hung ; Kim, Nam Kyu ; Min, Byung Soh ; Kim, Hoguen ; Koom, Woong Sub ; Shin, Sang Joon. / Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers. In: British journal of cancer. 2016 ; Vol. 115, No. 1. pp. 25-33.
@article{0f5cafd60bd24ff4b3fe00a3e01fb686,
title = "Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers",
abstract = "Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. Results: A total of 261 patients (8.9{\%}) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0{\%} vs 12.0{\%}, P=0.032) or peritoneal metastasis (40.0{\%} vs 12.3{\%}, P=0.003), and less frequent lung (10.0{\%} vs 42.5{\%}, P=0.004) or liver metastases (15.0{\%} vs 44.7{\%}, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. Conclusions: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.",
author = "Kim, {Chang Gon} and Ahn, {Joong Bae} and Minkyu Jung and Beom, {Seung Hoon} and Chan Kim and Kim, {Joo Hoon} and Heo, {Su Jin} and Park, {Hyung Soon} and Kim, {Jee Hung} and Kim, {Nam Kyu} and Min, {Byung Soh} and Hoguen Kim and Koom, {Woong Sub} and Shin, {Sang Joon}",
year = "2016",
month = "6",
day = "28",
doi = "10.1038/bjc.2016.161",
language = "English",
volume = "115",
pages = "25--33",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "1",

}

Kim, CG, Ahn, JB, Jung, M, Beom, SH, Kim, C, Kim, JH, Heo, SJ, Park, HS, Kim, JH, Kim, NK, Min, BS, Kim, H, Koom, WS & Shin, SJ 2016, 'Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers', British journal of cancer, vol. 115, no. 1, pp. 25-33. https://doi.org/10.1038/bjc.2016.161

Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers. / Kim, Chang Gon; Ahn, Joong Bae; Jung, Minkyu; Beom, Seung Hoon; Kim, Chan; Kim, Joo Hoon; Heo, Su Jin; Park, Hyung Soon; Kim, Jee Hung; Kim, Nam Kyu; Min, Byung Soh; Kim, Hoguen; Koom, Woong Sub; Shin, Sang Joon.

In: British journal of cancer, Vol. 115, No. 1, 28.06.2016, p. 25-33.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers

AU - Kim, Chang Gon

AU - Ahn, Joong Bae

AU - Jung, Minkyu

AU - Beom, Seung Hoon

AU - Kim, Chan

AU - Kim, Joo Hoon

AU - Heo, Su Jin

AU - Park, Hyung Soon

AU - Kim, Jee Hung

AU - Kim, Nam Kyu

AU - Min, Byung Soh

AU - Kim, Hoguen

AU - Koom, Woong Sub

AU - Shin, Sang Joon

PY - 2016/6/28

Y1 - 2016/6/28

N2 - Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. Results: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. Conclusions: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.

AB - Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. Results: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. Conclusions: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.

UR - http://www.scopus.com/inward/record.url?scp=84969916687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969916687&partnerID=8YFLogxK

U2 - 10.1038/bjc.2016.161

DO - 10.1038/bjc.2016.161

M3 - Article

C2 - 27228287

AN - SCOPUS:84969916687

VL - 115

SP - 25

EP - 33

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 1

ER -