Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery

Y. J. Oh, S. H. Kim, H. K. Shinn, C. S. Lee, Y. W. Hong, Younglan Kwak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. Jugular bulb oxygen saturation (Sjv O2 ) is a surrogate marker for global cerebral oxygenation. The effect of milrinone on Sjv O2 , and the cerebrovascular carbon dioxide reactivity (CCO2R) was investigated. Methods. Thirty patients scheduled for coronary artery bypass graft surgery (CABG) were studied prospectively. After sternotomy, normoventilation (at T 1 ; Pa CO2 =4.7-5.0 kPa) and hyperventilation (at T 2 ; Pa CO2 =3.3-3.7 kPa) were induced and the changes in Sjv O2 (ΔSjv O2 ) and Pa CO2 (ΔPa CO2 ), and ΔSjv O2 /ΔPa CO2 (CCO 2 R) were measured. After normoventilation was re-established (at T 3 ), milrinone 50 μg kg -1 was given (at T 4 ), followed by hyperventilation (at T 5 ), and ΔSjv O2 , ΔPa CO2 and CCO 2 R were measured. Results. After milrinone administration at normoventilation (T 3 and T 4 ), cardiac index and mixed venous oxygen saturation increased, while mean arterial pressure and systemic vascular resistance index decreased, without a significant change in Sjv O2 . Before milrinone administration (T 1 and T 2 ), hyperventilation decreased Pa CO2 and Sjv O2 , and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . After milrinone administration (T 4 and T 5 ), hyperventilation decreased Pa CO2 and Sjv O2 and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . There was no significant difference in CCO 2 R before and after milrinone administration (13.3 (5.7)% kPa -1 and 12.3 (3.9)% kPa- 1 , respectively). Conclusions. Although milrinone induced significant haemodynamic changes, Sjv O2 and CCO 2 R were unchanged during its administration.

Original languageEnglish
Pages (from-to)634-638
Number of pages5
JournalBritish Journal of Anaesthesia
Volume93
Issue number5
DOIs
Publication statusPublished - 2004 Jan 1

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Milrinone
Carbon Dioxide
Coronary Artery Bypass
Neck
Oxygen
Hyperventilation
Transplants
Sternotomy
Vascular Resistance
Arterial Pressure
Biomarkers
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

@article{99c4a61a49c748418ad76d5755ad7960,
title = "Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery",
abstract = "Background. Jugular bulb oxygen saturation (Sjv O2 ) is a surrogate marker for global cerebral oxygenation. The effect of milrinone on Sjv O2 , and the cerebrovascular carbon dioxide reactivity (CCO2R) was investigated. Methods. Thirty patients scheduled for coronary artery bypass graft surgery (CABG) were studied prospectively. After sternotomy, normoventilation (at T 1 ; Pa CO2 =4.7-5.0 kPa) and hyperventilation (at T 2 ; Pa CO2 =3.3-3.7 kPa) were induced and the changes in Sjv O2 (ΔSjv O2 ) and Pa CO2 (ΔPa CO2 ), and ΔSjv O2 /ΔPa CO2 (CCO 2 R) were measured. After normoventilation was re-established (at T 3 ), milrinone 50 μg kg -1 was given (at T 4 ), followed by hyperventilation (at T 5 ), and ΔSjv O2 , ΔPa CO2 and CCO 2 R were measured. Results. After milrinone administration at normoventilation (T 3 and T 4 ), cardiac index and mixed venous oxygen saturation increased, while mean arterial pressure and systemic vascular resistance index decreased, without a significant change in Sjv O2 . Before milrinone administration (T 1 and T 2 ), hyperventilation decreased Pa CO2 and Sjv O2 , and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . After milrinone administration (T 4 and T 5 ), hyperventilation decreased Pa CO2 and Sjv O2 and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . There was no significant difference in CCO 2 R before and after milrinone administration (13.3 (5.7){\%} kPa -1 and 12.3 (3.9){\%} kPa- 1 , respectively). Conclusions. Although milrinone induced significant haemodynamic changes, Sjv O2 and CCO 2 R were unchanged during its administration.",
author = "Oh, {Y. J.} and Kim, {S. H.} and Shinn, {H. K.} and Lee, {C. S.} and Hong, {Y. W.} and Younglan Kwak",
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Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery. / Oh, Y. J.; Kim, S. H.; Shinn, H. K.; Lee, C. S.; Hong, Y. W.; Kwak, Younglan.

In: British Journal of Anaesthesia, Vol. 93, No. 5, 01.01.2004, p. 634-638.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery

AU - Oh, Y. J.

AU - Kim, S. H.

AU - Shinn, H. K.

AU - Lee, C. S.

AU - Hong, Y. W.

AU - Kwak, Younglan

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background. Jugular bulb oxygen saturation (Sjv O2 ) is a surrogate marker for global cerebral oxygenation. The effect of milrinone on Sjv O2 , and the cerebrovascular carbon dioxide reactivity (CCO2R) was investigated. Methods. Thirty patients scheduled for coronary artery bypass graft surgery (CABG) were studied prospectively. After sternotomy, normoventilation (at T 1 ; Pa CO2 =4.7-5.0 kPa) and hyperventilation (at T 2 ; Pa CO2 =3.3-3.7 kPa) were induced and the changes in Sjv O2 (ΔSjv O2 ) and Pa CO2 (ΔPa CO2 ), and ΔSjv O2 /ΔPa CO2 (CCO 2 R) were measured. After normoventilation was re-established (at T 3 ), milrinone 50 μg kg -1 was given (at T 4 ), followed by hyperventilation (at T 5 ), and ΔSjv O2 , ΔPa CO2 and CCO 2 R were measured. Results. After milrinone administration at normoventilation (T 3 and T 4 ), cardiac index and mixed venous oxygen saturation increased, while mean arterial pressure and systemic vascular resistance index decreased, without a significant change in Sjv O2 . Before milrinone administration (T 1 and T 2 ), hyperventilation decreased Pa CO2 and Sjv O2 , and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . After milrinone administration (T 4 and T 5 ), hyperventilation decreased Pa CO2 and Sjv O2 and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . There was no significant difference in CCO 2 R before and after milrinone administration (13.3 (5.7)% kPa -1 and 12.3 (3.9)% kPa- 1 , respectively). Conclusions. Although milrinone induced significant haemodynamic changes, Sjv O2 and CCO 2 R were unchanged during its administration.

AB - Background. Jugular bulb oxygen saturation (Sjv O2 ) is a surrogate marker for global cerebral oxygenation. The effect of milrinone on Sjv O2 , and the cerebrovascular carbon dioxide reactivity (CCO2R) was investigated. Methods. Thirty patients scheduled for coronary artery bypass graft surgery (CABG) were studied prospectively. After sternotomy, normoventilation (at T 1 ; Pa CO2 =4.7-5.0 kPa) and hyperventilation (at T 2 ; Pa CO2 =3.3-3.7 kPa) were induced and the changes in Sjv O2 (ΔSjv O2 ) and Pa CO2 (ΔPa CO2 ), and ΔSjv O2 /ΔPa CO2 (CCO 2 R) were measured. After normoventilation was re-established (at T 3 ), milrinone 50 μg kg -1 was given (at T 4 ), followed by hyperventilation (at T 5 ), and ΔSjv O2 , ΔPa CO2 and CCO 2 R were measured. Results. After milrinone administration at normoventilation (T 3 and T 4 ), cardiac index and mixed venous oxygen saturation increased, while mean arterial pressure and systemic vascular resistance index decreased, without a significant change in Sjv O2 . Before milrinone administration (T 1 and T 2 ), hyperventilation decreased Pa CO2 and Sjv O2 , and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . After milrinone administration (T 4 and T 5 ), hyperventilation decreased Pa CO2 and Sjv O2 and ΔSjv O2 showed positive linear correlation with ΔPa CO2 . There was no significant difference in CCO 2 R before and after milrinone administration (13.3 (5.7)% kPa -1 and 12.3 (3.9)% kPa- 1 , respectively). Conclusions. Although milrinone induced significant haemodynamic changes, Sjv O2 and CCO 2 R were unchanged during its administration.

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DO - 10.1093/bja/aeh252

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