Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages

Eun Mi Choi; Jae Kwan Hwang

doi:10.1016/j.fitote.2005.05.006

Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E₂ and cytokines in RAW264.7 macrophages

Eun Mi Choi, Jae Kwan Hwang

Research output: Contribution to journal › Article

62 Citations (Scopus)

Abstract

Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE₂ production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.

Original language	English
Pages (from-to)	608-613
Number of pages	6
Journal	Fitoterapia
Volume	76
Issue number	7-8
DOIs	https://doi.org/10.1016/j.fitote.2005.05.006
Publication status	Published - 2005 Dec 1

Fingerprint

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

Cite this

Choi, E. M., & Hwang, J. K. (2005). Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E₂ and cytokines in RAW264.7 macrophages. Fitoterapia, 76(7-8), 608-613. https://doi.org/10.1016/j.fitote.2005.05.006

@article{3a60031bb72f4870bf2096a95a4eaaa5,

title = "Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages",

abstract = "Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.",

author = "Choi, {Eun Mi} and Hwang, {Jae Kwan}",

year = "2005",

month = dec,

day = "1",

doi = "10.1016/j.fitote.2005.05.006",

language = "English",

volume = "76",

pages = "608--613",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier",

number = "7-8",

}

TY - JOUR

T1 - Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages

AU - Choi, Eun Mi

AU - Hwang, Jae Kwan

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.

AB - Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.

UR - http://www.scopus.com/inward/record.url?scp=28044436308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28044436308&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2005.05.006

DO - 10.1016/j.fitote.2005.05.006

M3 - Article

C2 - 16229967

AN - SCOPUS:28044436308

VL - 76

SP - 608

EP - 613

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 7-8

ER -

Access to Document

10.1016/j.fitote.2005.05.006