Abstract
Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.
| Original language | English |
|---|---|
| Pages (from-to) | 608-613 |
| Number of pages | 6 |
| Journal | Fitoterapia |
| Volume | 76 |
| Issue number | 7-8 |
| DOIs | |
| Publication status | Published - 2005 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
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Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. / Choi, Eun Mi; Hwang, Jae Kwan.
In: Fitoterapia, Vol. 76, No. 7-8, 01.12.2005, p. 608-613.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages
AU - Choi, Eun Mi
AU - Hwang, Jae Kwan
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.
AB - Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.
UR - http://www.scopus.com/inward/record.url?scp=28044436308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28044436308&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2005.05.006
DO - 10.1016/j.fitote.2005.05.006
M3 - Article
C2 - 16229967
AN - SCOPUS:28044436308
VL - 76
SP - 608
EP - 613
JO - Fitoterapia
JF - Fitoterapia
SN - 0367-326X
IS - 7-8
ER -