Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages

Eun Mi Choi, Jae-Kwan Hwang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.

Original languageEnglish
Pages (from-to)608-613
Number of pages6
JournalFitoterapia
Volume76
Issue number7-8
DOIs
Publication statusPublished - 2005 Dec 1

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Morus
Butanols
Dinoprostone
Nitric Oxide
Macrophages
Cytokines
Chloroform
Anti-Inflammatory Agents

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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abstract = "Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.",
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Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. / Choi, Eun Mi; Hwang, Jae-Kwan.

In: Fitoterapia, Vol. 76, No. 7-8, 01.12.2005, p. 608-613.

Research output: Contribution to journalArticle

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