Abstract
Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 μg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-α. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents.
Original language | English |
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Pages (from-to) | 608-613 |
Number of pages | 6 |
Journal | Fitoterapia |
Volume | 76 |
Issue number | 7-8 |
DOIs | |
Publication status | Published - 2005 Dec |
Bibliographical note
Funding Information:The work was supported by the Korea Research Foundation Grant (KRF-2002-037-F00013).
All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery