Effects of nattokinase on blood pressure: A randomized, controlled trial

Ji Young Kim, Si Nae Gum, Jean Kyung Paik, Hyo Hee Lim, Kyong Chol Kim, Kazuya Ogasawara, Kenichi Inoue, Sungha Park, Yangsoo Jang, Jong Ho Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

Original languageEnglish
Pages (from-to)1583-1588
Number of pages6
JournalHypertension Research
Volume31
Issue number8
DOIs
Publication statusPublished - 2008 Jan 1

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Randomized Controlled Trials
Blood Pressure
Capsules
nattokinase
Placebos
Prehypertension
Confidence Intervals
Hypertension
Control Groups
Renin

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., ... Lee, J. H. (2008). Effects of nattokinase on blood pressure: A randomized, controlled trial. Hypertension Research, 31(8), 1583-1588. https://doi.org/10.1291/hypres.31.1583
Kim, Ji Young ; Gum, Si Nae ; Paik, Jean Kyung ; Lim, Hyo Hee ; Kim, Kyong Chol ; Ogasawara, Kazuya ; Inoue, Kenichi ; Park, Sungha ; Jang, Yangsoo ; Lee, Jong Ho. / Effects of nattokinase on blood pressure : A randomized, controlled trial. In: Hypertension Research. 2008 ; Vol. 31, No. 8. pp. 1583-1588.
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Kim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, Ogasawara, K, Inoue, K, Park, S, Jang, Y & Lee, JH 2008, 'Effects of nattokinase on blood pressure: A randomized, controlled trial', Hypertension Research, vol. 31, no. 8, pp. 1583-1588. https://doi.org/10.1291/hypres.31.1583

Effects of nattokinase on blood pressure : A randomized, controlled trial. / Kim, Ji Young; Gum, Si Nae; Paik, Jean Kyung; Lim, Hyo Hee; Kim, Kyong Chol; Ogasawara, Kazuya; Inoue, Kenichi; Park, Sungha; Jang, Yangsoo; Lee, Jong Ho.

In: Hypertension Research, Vol. 31, No. 8, 01.01.2008, p. 1583-1588.

Research output: Contribution to journalArticle

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Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, Ogasawara K et al. Effects of nattokinase on blood pressure: A randomized, controlled trial. Hypertension Research. 2008 Jan 1;31(8):1583-1588. https://doi.org/10.1291/hypres.31.1583