Effects of neoadjuvant combined chemotherapy and radiation therapy on the CT evaluation respectability and staging in patients with pancreatic head cancer

Yeo Eun Kim, Mi Suk Park, Hye Suk Hong, ChangMoo Kang, Jin Young Choi, Joon Seok Lim, Woo Jung Lee, Myeong Jin Kim, Ki Whang Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose: To evaluate the effectof neoaduunvat comhined chemothorayv and radiation therapy (CCRT) on preoperative accuracv of multidetector computed tomography (CT) for resectability and tumor staging in patients with pancreatic head rancor. Materials and Methods: This retrospective study received institutional review board approval and was exempted from informed consent requirements, from May 2002 to March 2007, 38 patients with pancreatic head adenocarcinoma underwent multidetector CT before surgery. Of these. 12 patients received neoadjuvant CCRT. Imaging findings were evaluated for tumor resectability and tumor staging. Surgical and pathologic results were used as the reference standard. The accuracy of resectability and individual components of each T category were compared belween the patients with neoadjuvant CCRT and wiihoui it by using the X 2 test or fisher evict test. A P of less than .05 was considered as significant. Results: The accuracy in determining resectability was 83% (10 of12) in patients who had received neoadjuvant CCRT and 81 % (21 of 26) in patients who had not, without significant difference (P> .05). Of 32 patients who underwent pancreaticoduodenectomy, histopathologic tumor staying was reported for T1 [n = 2), T2 (n = I), and T3 (n = 9 lesions in patents with neoadjuvant CCRT (n = 12). and for T3 in all patients without neoadjuvant CCRT (n = 20). T-staging accuracy was 67% (eight of 12) with neoadjuvant CCRT and 95% (19 of 20) without it, with a significant difference (P = .0815). Conclusion: Neoadjuvant CCRT reduces the accuracy of tumor restaging after treatment, of pancreatic head cancer, but this effect is not so great as to affect die determination of resectability.

Original languageEnglish
Pages (from-to)758-765
Number of pages8
JournalRadiology
Volume250
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Head and Neck Neoplasms
Pancreatic Neoplasms
Radiotherapy
Tomography
Drug Therapy
Multidetector Computed Tomography
Neoplasm Staging
Neoplasms
Pancreaticoduodenectomy
Patents
Research Ethics Committees
Informed Consent
Adenocarcinoma
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Yeo Eun ; Park, Mi Suk ; Hong, Hye Suk ; Kang, ChangMoo ; Choi, Jin Young ; Lim, Joon Seok ; Lee, Woo Jung ; Kim, Myeong Jin ; Kim, Ki Whang. / Effects of neoadjuvant combined chemotherapy and radiation therapy on the CT evaluation respectability and staging in patients with pancreatic head cancer. In: Radiology. 2009 ; Vol. 250, No. 3. pp. 758-765.
@article{48f0f440b08d4141b0aae5b6a259a4c8,
title = "Effects of neoadjuvant combined chemotherapy and radiation therapy on the CT evaluation respectability and staging in patients with pancreatic head cancer",
abstract = "Purpose: To evaluate the effectof neoaduunvat comhined chemothorayv and radiation therapy (CCRT) on preoperative accuracv of multidetector computed tomography (CT) for resectability and tumor staging in patients with pancreatic head rancor. Materials and Methods: This retrospective study received institutional review board approval and was exempted from informed consent requirements, from May 2002 to March 2007, 38 patients with pancreatic head adenocarcinoma underwent multidetector CT before surgery. Of these. 12 patients received neoadjuvant CCRT. Imaging findings were evaluated for tumor resectability and tumor staging. Surgical and pathologic results were used as the reference standard. The accuracy of resectability and individual components of each T category were compared belween the patients with neoadjuvant CCRT and wiihoui it by using the X 2 test or fisher evict test. A P of less than .05 was considered as significant. Results: The accuracy in determining resectability was 83{\%} (10 of12) in patients who had received neoadjuvant CCRT and 81 {\%} (21 of 26) in patients who had not, without significant difference (P> .05). Of 32 patients who underwent pancreaticoduodenectomy, histopathologic tumor staying was reported for T1 [n = 2), T2 (n = I), and T3 (n = 9 lesions in patents with neoadjuvant CCRT (n = 12). and for T3 in all patients without neoadjuvant CCRT (n = 20). T-staging accuracy was 67{\%} (eight of 12) with neoadjuvant CCRT and 95{\%} (19 of 20) without it, with a significant difference (P = .0815). Conclusion: Neoadjuvant CCRT reduces the accuracy of tumor restaging after treatment, of pancreatic head cancer, but this effect is not so great as to affect die determination of resectability.",
author = "Kim, {Yeo Eun} and Park, {Mi Suk} and Hong, {Hye Suk} and ChangMoo Kang and Choi, {Jin Young} and Lim, {Joon Seok} and Lee, {Woo Jung} and Kim, {Myeong Jin} and Kim, {Ki Whang}",
year = "2009",
month = "3",
day = "1",
doi = "10.1148/radiol.2502080501",
language = "English",
volume = "250",
pages = "758--765",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

Effects of neoadjuvant combined chemotherapy and radiation therapy on the CT evaluation respectability and staging in patients with pancreatic head cancer. / Kim, Yeo Eun; Park, Mi Suk; Hong, Hye Suk; Kang, ChangMoo; Choi, Jin Young; Lim, Joon Seok; Lee, Woo Jung; Kim, Myeong Jin; Kim, Ki Whang.

In: Radiology, Vol. 250, No. 3, 01.03.2009, p. 758-765.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of neoadjuvant combined chemotherapy and radiation therapy on the CT evaluation respectability and staging in patients with pancreatic head cancer

AU - Kim, Yeo Eun

AU - Park, Mi Suk

AU - Hong, Hye Suk

AU - Kang, ChangMoo

AU - Choi, Jin Young

AU - Lim, Joon Seok

AU - Lee, Woo Jung

AU - Kim, Myeong Jin

AU - Kim, Ki Whang

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Purpose: To evaluate the effectof neoaduunvat comhined chemothorayv and radiation therapy (CCRT) on preoperative accuracv of multidetector computed tomography (CT) for resectability and tumor staging in patients with pancreatic head rancor. Materials and Methods: This retrospective study received institutional review board approval and was exempted from informed consent requirements, from May 2002 to March 2007, 38 patients with pancreatic head adenocarcinoma underwent multidetector CT before surgery. Of these. 12 patients received neoadjuvant CCRT. Imaging findings were evaluated for tumor resectability and tumor staging. Surgical and pathologic results were used as the reference standard. The accuracy of resectability and individual components of each T category were compared belween the patients with neoadjuvant CCRT and wiihoui it by using the X 2 test or fisher evict test. A P of less than .05 was considered as significant. Results: The accuracy in determining resectability was 83% (10 of12) in patients who had received neoadjuvant CCRT and 81 % (21 of 26) in patients who had not, without significant difference (P> .05). Of 32 patients who underwent pancreaticoduodenectomy, histopathologic tumor staying was reported for T1 [n = 2), T2 (n = I), and T3 (n = 9 lesions in patents with neoadjuvant CCRT (n = 12). and for T3 in all patients without neoadjuvant CCRT (n = 20). T-staging accuracy was 67% (eight of 12) with neoadjuvant CCRT and 95% (19 of 20) without it, with a significant difference (P = .0815). Conclusion: Neoadjuvant CCRT reduces the accuracy of tumor restaging after treatment, of pancreatic head cancer, but this effect is not so great as to affect die determination of resectability.

AB - Purpose: To evaluate the effectof neoaduunvat comhined chemothorayv and radiation therapy (CCRT) on preoperative accuracv of multidetector computed tomography (CT) for resectability and tumor staging in patients with pancreatic head rancor. Materials and Methods: This retrospective study received institutional review board approval and was exempted from informed consent requirements, from May 2002 to March 2007, 38 patients with pancreatic head adenocarcinoma underwent multidetector CT before surgery. Of these. 12 patients received neoadjuvant CCRT. Imaging findings were evaluated for tumor resectability and tumor staging. Surgical and pathologic results were used as the reference standard. The accuracy of resectability and individual components of each T category were compared belween the patients with neoadjuvant CCRT and wiihoui it by using the X 2 test or fisher evict test. A P of less than .05 was considered as significant. Results: The accuracy in determining resectability was 83% (10 of12) in patients who had received neoadjuvant CCRT and 81 % (21 of 26) in patients who had not, without significant difference (P> .05). Of 32 patients who underwent pancreaticoduodenectomy, histopathologic tumor staying was reported for T1 [n = 2), T2 (n = I), and T3 (n = 9 lesions in patents with neoadjuvant CCRT (n = 12). and for T3 in all patients without neoadjuvant CCRT (n = 20). T-staging accuracy was 67% (eight of 12) with neoadjuvant CCRT and 95% (19 of 20) without it, with a significant difference (P = .0815). Conclusion: Neoadjuvant CCRT reduces the accuracy of tumor restaging after treatment, of pancreatic head cancer, but this effect is not so great as to affect die determination of resectability.

UR - http://www.scopus.com/inward/record.url?scp=62649100772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62649100772&partnerID=8YFLogxK

U2 - 10.1148/radiol.2502080501

DO - 10.1148/radiol.2502080501

M3 - Article

C2 - 19164113

AN - SCOPUS:62649100772

VL - 250

SP - 758

EP - 765

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

ER -