Abstract
Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 410-414 |
| Number of pages | 5 |
| Journal | BMB reports |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2011 Jun 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
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Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro. / Bak, Eun Jung; Park, Hong Gyu; Lee, Choong Hwan; Lee, Tong Il; Woo, Gye Hyeong; Na, Younghwa; Yoo, Yun Jung; Cha, Jeong Heon.
In: BMB reports, Vol. 44, No. 6, 01.06.2011, p. 410-414.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro
AU - Bak, Eun Jung
AU - Park, Hong Gyu
AU - Lee, Choong Hwan
AU - Lee, Tong Il
AU - Woo, Gye Hyeong
AU - Na, Younghwa
AU - Yoo, Yun Jung
AU - Cha, Jeong Heon
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.
AB - Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=79960089642&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960089642&partnerID=8YFLogxK
U2 - 10.5483/BMBRep.2011.44.6.410
DO - 10.5483/BMBRep.2011.44.6.410
M3 - Article
C2 - 21699755
AN - SCOPUS:79960089642
VL - 44
SP - 410
EP - 414
JO - BMB Reports
JF - BMB Reports
SN - 1976-6696
IS - 6
ER -