Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro

Eun Jung Bak; Hong Gyu Park; Choong Hwan Lee; Tong Il Lee; Gye Hyeong Woo; Younghwa Na; Yun Jung Yoo; Jeong Heon Cha

doi:10.5483/BMBRep.2011.44.6.410

Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro

Eun Jung Bak, Hong Gyu Park, Choong Hwan Lee, Tong Il Lee, Gye Hyeong Woo, Younghwa Na, Yun Jung Yoo, Jeong Heon Cha

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.

Original language	English
Pages (from-to)	410-414
Number of pages	5
Journal	BMB reports
Volume	44
Issue number	6
DOIs	https://doi.org/10.5483/BMBRep.2011.44.6.410
Publication status	Published - 2011 Jun

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Biochemistry
Molecular Biology

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title = "Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro",

abstract = "Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.",

author = "Bak, {Eun Jung} and Park, {Hong Gyu} and Lee, {Choong Hwan} and Lee, {Tong Il} and Woo, {Gye Hyeong} and Younghwa Na and Yoo, {Yun Jung} and Cha, {Jeong Heon}",

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language = "English",

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Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro. / Bak, Eun Jung; Park, Hong Gyu; Lee, Choong Hwan; Lee, Tong Il; Woo, Gye Hyeong; Na, Younghwa; Yoo, Yun Jung; Cha, Jeong Heon.

In: BMB reports, Vol. 44, No. 6, 06.2011, p. 410-414.

Research output: Contribution to journal › Article › peer-review

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AU - Bak, Eun Jung

AU - Park, Hong Gyu

AU - Lee, Choong Hwan

AU - Lee, Tong Il

AU - Woo, Gye Hyeong

AU - Na, Younghwa

AU - Yoo, Yun Jung

AU - Cha, Jeong Heon

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Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro

Abstract

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