Effects of oligonol on the submandibular gland in ovariectomized rats

Jeong Hun Kim, Hyangkyu Lee, Ji Min Kim, Hyung Sik Kim, Sung Chan Shin, Sun Kyung Hwang, Byung Joo Lee, Keunyoung Kim

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3 Citations (Scopus)


The aim of this study was to observe the effects of oligonol on submandibular gland dysfunction in ovariectomized rats. We randomly divided female Sprague-Dawley rats into sham-operated, ovariectomized, and oligonol-treated ovariectomized groups. Oligonol was intraperitoneally administered at 30 mg/kg daily for six weeks. Lipogenesis increased after the ovariectomy while fatty acid oxidation increased and intracellular triglyceride levels decreased in response to oligonol treatment. Submandibular gland fibrosis characterized by collagen type I accumulation was observed in the ovariectomized group. However, oligonol markedly reduced fibrosis to a level comparable to that observed in the sham group. Aquaporin 1 and glucose transporter 4 were downregulated in the ovariectomized group. Nevertheless, both factors were significantly upregulated by oligonol treatment. However, aquaporin 5 was significantly downregulated in the oligonol treatment group. Our findings indicate that oligonol protects against damage in postmenopausal rat salivary glands.

Original languageEnglish
Article number111897
JournalBiomedicine and Pharmacotherapy
Publication statusPublished - 2021 Sept

Bibliographical note

Funding Information:
This work was financially supported by the Faculty Research Assistance Program of Yonsei University College of Nursing (No. 6-2013-0178 ) and a National Research Foundation of Korea Grant from the Korean Government (No. NRF-2012R1A12042620 ) to H. Lee. We would like to thank Editage ( www.editage.co.kr ) for English language editing.

Publisher Copyright:
© 2021 The Authors

All Science Journal Classification (ASJC) codes

  • Pharmacology


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