Effects of perianal involvement on clinical outcomes in Crohn's disease over 10 years

Jin Young Yoon, Jae Hee Cheon, Soo Jung Park, Tae Il Kim, Won Ho Kim

Research output: Contribution to journalArticle

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Abstract

Background/Aims: There was the assumption that Crohn's disease (CD) patients with perianal lesions might have different clinical courses compared to those without. However, quantifiable data comparing the long-term outcomes between the two groups are scarce. Methods: We retrospectively reviewed 221 consecutive patients newly diagnosed with CD and registered at the IBD clinic of Severance Hospital, in Seoul, Korea, between January 1990 and October 2005. We compared patients with perianal CD (PCD) and non-perianal CD (NPCD) in terms of clinical outcomes over 10 years. Results: PCD progressed more frequently from inflammatory to complicated behavior than NPCD. Moreover, corticosteroids were prescribed in 102 patients with PCD and only 57 with NPCD (82.9% vs 58.2%, p<0.001), immunosuppressants in 89 and 42 (72.4% vs 42.9%, p<0.001), and anti-tumor necrosis factor α (TNF-α) in 37 and 12 (30.1% vs 12.2%, p=0.002). Cumulative hospitalization rates were 82.1% in PCD and 72.4% in NPCD (p=0.086), and surgical intervention rates were 39.8% and 51.0%, respectively (p=0.097). Conclusions: Patients with PCD were more likely than those with NPCD to be administered corticosteroids, immunosuppressants, and anti-TNF-α. However, there is no significant difference in the cumulative rates of surgical interventions or hospitalizations.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalGut and liver
Volume12
Issue number3
DOIs
Publication statusPublished - 2018 May

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Crohn Disease
Immunosuppressive Agents
Adrenal Cortex Hormones
Hospitalization
Korea
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Yoon, Jin Young ; Cheon, Jae Hee ; Park, Soo Jung ; Kim, Tae Il ; Kim, Won Ho. / Effects of perianal involvement on clinical outcomes in Crohn's disease over 10 years. In: Gut and liver. 2018 ; Vol. 12, No. 3. pp. 297-305.
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abstract = "Background/Aims: There was the assumption that Crohn's disease (CD) patients with perianal lesions might have different clinical courses compared to those without. However, quantifiable data comparing the long-term outcomes between the two groups are scarce. Methods: We retrospectively reviewed 221 consecutive patients newly diagnosed with CD and registered at the IBD clinic of Severance Hospital, in Seoul, Korea, between January 1990 and October 2005. We compared patients with perianal CD (PCD) and non-perianal CD (NPCD) in terms of clinical outcomes over 10 years. Results: PCD progressed more frequently from inflammatory to complicated behavior than NPCD. Moreover, corticosteroids were prescribed in 102 patients with PCD and only 57 with NPCD (82.9{\%} vs 58.2{\%}, p<0.001), immunosuppressants in 89 and 42 (72.4{\%} vs 42.9{\%}, p<0.001), and anti-tumor necrosis factor α (TNF-α) in 37 and 12 (30.1{\%} vs 12.2{\%}, p=0.002). Cumulative hospitalization rates were 82.1{\%} in PCD and 72.4{\%} in NPCD (p=0.086), and surgical intervention rates were 39.8{\%} and 51.0{\%}, respectively (p=0.097). Conclusions: Patients with PCD were more likely than those with NPCD to be administered corticosteroids, immunosuppressants, and anti-TNF-α. However, there is no significant difference in the cumulative rates of surgical interventions or hospitalizations.",
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Effects of perianal involvement on clinical outcomes in Crohn's disease over 10 years. / Yoon, Jin Young; Cheon, Jae Hee; Park, Soo Jung; Kim, Tae Il; Kim, Won Ho.

In: Gut and liver, Vol. 12, No. 3, 05.2018, p. 297-305.

Research output: Contribution to journalArticle

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