Effects of previous or synchronous non-muscle invasive bladder cancer on clinical results after radical nephroureterectomy for upper tract urothelial carcinoma: A multi-institutional study

Bup Wan Kim, Yun Sok Ha, Jun Nyung Lee, Hyun Tae Kim, Tae Hwan Kim, Jung Keun Lee, Seok Soo Byun, Young Deuk Choi, Ho Won Kang, Seok Joong Yun, Wun Jae Kim, Young Suk Kwon, Tae Gyun Kwon

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Abstract

Purpose: To evaluate the effects of the presence of previous or synchronous non-muscle invasive bladder cancer (NMIBC) on the oncologic outcomes of radical nephroureterectomy in patients with upper tract urothelial carcinoma (UTUC). Materials and Methods: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathologic parameters of patients with and without previous or synchronous NMIBC were compared, and Kaplan-Meier estimates and multivariate Cox regression analyses were performed. Results: The median follow-up period was 38.4 months. In all, 408 patients had primary UTUC, 45 (8.9%) had a history of NMIBC, 59 (11.7%) had concomitant bladder cancer, and seven (1.4%) had experienced both. Tumors in patients with associated NMIBC were more commonly multifocal (P =.001) and associated with surgical margin positivity (P =.001). Kaplan-Meier estimates revealed that previous or synchronous NMIBC was significantly associated with bladder recurrence (P <.001) and locoregional recurrence/distant metastasis (P =.008). A multivariate Cox regression model identified previous or synchronous NMIBC as an independent predictor of bladder recurrence (P <.001). However, the presence of previous or synchronous NMIBC was not a prognostic indicator of locoregional recurrence/distant metastasis. Conclusion: In patients with UTUC, previous or synchronous NMIBC was significantly associated with an increased risk of cancer recurrences in the bladder after radical nephroureterectomy. The present findings suggest that a close monitoring should be required for the patients with previous or concomitant NMIBC.

Original languageEnglish
Pages (from-to)2233-2239
Number of pages7
JournalUrology Journal
Volume12
Issue number4
Publication statusPublished - 2015 Jan 1

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Urinary Bladder Neoplasms
Carcinoma
Recurrence
Urinary Bladder
Kaplan-Meier Estimate
Neoplasm Metastasis
Proportional Hazards Models
Neoplasms
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Kim, Bup Wan ; Ha, Yun Sok ; Lee, Jun Nyung ; Kim, Hyun Tae ; Kim, Tae Hwan ; Lee, Jung Keun ; Byun, Seok Soo ; Choi, Young Deuk ; Kang, Ho Won ; Yun, Seok Joong ; Kim, Wun Jae ; Kwon, Young Suk ; Kwon, Tae Gyun. / Effects of previous or synchronous non-muscle invasive bladder cancer on clinical results after radical nephroureterectomy for upper tract urothelial carcinoma : A multi-institutional study. In: Urology Journal. 2015 ; Vol. 12, No. 4. pp. 2233-2239.
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title = "Effects of previous or synchronous non-muscle invasive bladder cancer on clinical results after radical nephroureterectomy for upper tract urothelial carcinoma: A multi-institutional study",
abstract = "Purpose: To evaluate the effects of the presence of previous or synchronous non-muscle invasive bladder cancer (NMIBC) on the oncologic outcomes of radical nephroureterectomy in patients with upper tract urothelial carcinoma (UTUC). Materials and Methods: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathologic parameters of patients with and without previous or synchronous NMIBC were compared, and Kaplan-Meier estimates and multivariate Cox regression analyses were performed. Results: The median follow-up period was 38.4 months. In all, 408 patients had primary UTUC, 45 (8.9{\%}) had a history of NMIBC, 59 (11.7{\%}) had concomitant bladder cancer, and seven (1.4{\%}) had experienced both. Tumors in patients with associated NMIBC were more commonly multifocal (P =.001) and associated with surgical margin positivity (P =.001). Kaplan-Meier estimates revealed that previous or synchronous NMIBC was significantly associated with bladder recurrence (P <.001) and locoregional recurrence/distant metastasis (P =.008). A multivariate Cox regression model identified previous or synchronous NMIBC as an independent predictor of bladder recurrence (P <.001). However, the presence of previous or synchronous NMIBC was not a prognostic indicator of locoregional recurrence/distant metastasis. Conclusion: In patients with UTUC, previous or synchronous NMIBC was significantly associated with an increased risk of cancer recurrences in the bladder after radical nephroureterectomy. The present findings suggest that a close monitoring should be required for the patients with previous or concomitant NMIBC.",
author = "Kim, {Bup Wan} and Ha, {Yun Sok} and Lee, {Jun Nyung} and Kim, {Hyun Tae} and Kim, {Tae Hwan} and Lee, {Jung Keun} and Byun, {Seok Soo} and Choi, {Young Deuk} and Kang, {Ho Won} and Yun, {Seok Joong} and Kim, {Wun Jae} and Kwon, {Young Suk} and Kwon, {Tae Gyun}",
year = "2015",
month = "1",
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language = "English",
volume = "12",
pages = "2233--2239",
journal = "Urology Journal",
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Kim, BW, Ha, YS, Lee, JN, Kim, HT, Kim, TH, Lee, JK, Byun, SS, Choi, YD, Kang, HW, Yun, SJ, Kim, WJ, Kwon, YS & Kwon, TG 2015, 'Effects of previous or synchronous non-muscle invasive bladder cancer on clinical results after radical nephroureterectomy for upper tract urothelial carcinoma: A multi-institutional study', Urology Journal, vol. 12, no. 4, pp. 2233-2239.

Effects of previous or synchronous non-muscle invasive bladder cancer on clinical results after radical nephroureterectomy for upper tract urothelial carcinoma : A multi-institutional study. / Kim, Bup Wan; Ha, Yun Sok; Lee, Jun Nyung; Kim, Hyun Tae; Kim, Tae Hwan; Lee, Jung Keun; Byun, Seok Soo; Choi, Young Deuk; Kang, Ho Won; Yun, Seok Joong; Kim, Wun Jae; Kwon, Young Suk; Kwon, Tae Gyun.

In: Urology Journal, Vol. 12, No. 4, 01.01.2015, p. 2233-2239.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of previous or synchronous non-muscle invasive bladder cancer on clinical results after radical nephroureterectomy for upper tract urothelial carcinoma

T2 - A multi-institutional study

AU - Kim, Bup Wan

AU - Ha, Yun Sok

AU - Lee, Jun Nyung

AU - Kim, Hyun Tae

AU - Kim, Tae Hwan

AU - Lee, Jung Keun

AU - Byun, Seok Soo

AU - Choi, Young Deuk

AU - Kang, Ho Won

AU - Yun, Seok Joong

AU - Kim, Wun Jae

AU - Kwon, Young Suk

AU - Kwon, Tae Gyun

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: To evaluate the effects of the presence of previous or synchronous non-muscle invasive bladder cancer (NMIBC) on the oncologic outcomes of radical nephroureterectomy in patients with upper tract urothelial carcinoma (UTUC). Materials and Methods: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathologic parameters of patients with and without previous or synchronous NMIBC were compared, and Kaplan-Meier estimates and multivariate Cox regression analyses were performed. Results: The median follow-up period was 38.4 months. In all, 408 patients had primary UTUC, 45 (8.9%) had a history of NMIBC, 59 (11.7%) had concomitant bladder cancer, and seven (1.4%) had experienced both. Tumors in patients with associated NMIBC were more commonly multifocal (P =.001) and associated with surgical margin positivity (P =.001). Kaplan-Meier estimates revealed that previous or synchronous NMIBC was significantly associated with bladder recurrence (P <.001) and locoregional recurrence/distant metastasis (P =.008). A multivariate Cox regression model identified previous or synchronous NMIBC as an independent predictor of bladder recurrence (P <.001). However, the presence of previous or synchronous NMIBC was not a prognostic indicator of locoregional recurrence/distant metastasis. Conclusion: In patients with UTUC, previous or synchronous NMIBC was significantly associated with an increased risk of cancer recurrences in the bladder after radical nephroureterectomy. The present findings suggest that a close monitoring should be required for the patients with previous or concomitant NMIBC.

AB - Purpose: To evaluate the effects of the presence of previous or synchronous non-muscle invasive bladder cancer (NMIBC) on the oncologic outcomes of radical nephroureterectomy in patients with upper tract urothelial carcinoma (UTUC). Materials and Methods: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathologic parameters of patients with and without previous or synchronous NMIBC were compared, and Kaplan-Meier estimates and multivariate Cox regression analyses were performed. Results: The median follow-up period was 38.4 months. In all, 408 patients had primary UTUC, 45 (8.9%) had a history of NMIBC, 59 (11.7%) had concomitant bladder cancer, and seven (1.4%) had experienced both. Tumors in patients with associated NMIBC were more commonly multifocal (P =.001) and associated with surgical margin positivity (P =.001). Kaplan-Meier estimates revealed that previous or synchronous NMIBC was significantly associated with bladder recurrence (P <.001) and locoregional recurrence/distant metastasis (P =.008). A multivariate Cox regression model identified previous or synchronous NMIBC as an independent predictor of bladder recurrence (P <.001). However, the presence of previous or synchronous NMIBC was not a prognostic indicator of locoregional recurrence/distant metastasis. Conclusion: In patients with UTUC, previous or synchronous NMIBC was significantly associated with an increased risk of cancer recurrences in the bladder after radical nephroureterectomy. The present findings suggest that a close monitoring should be required for the patients with previous or concomitant NMIBC.

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JO - Urology Journal

JF - Urology Journal

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