Effects of probiotics (cultured Lactobacillus subtilis/ Streptococcus faecium) in the treatment of alcoholic hepatitis

Randomized-controlled multicenter study

Sang Hak Han, Ki Tae Suk, Dong Joon Kim, Moonyoung Kim, Soonkoo Baik, Young Don Kim, Gab Jin Cheon, Dae Hee Choi, Young Lim Ham, Dong Hoon Shin, Eun Ji Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background Probiotics might reduce gut-derived microbial lipopolysaccharide (LPS) by restoring bowel flora in patients with alcoholic hepatitis (AH). We evaluated the therapeutic effects of probiotics in patients with AH. Patients and methods Between September 2010 and April 2012, 117 patients (probiotics 60 and placebo 57) were prospectively randomized to receive the 7 days of cultured Lactobacillus subtilis/Streptococcus faecium (1500 mg/day) or placebo. All patients were hospitalized and were not permitted to consume alcohol for the 7 days of the study. Liver function test, proinflammatory cytokines, LPS, and colony-forming units by stool culture were examined and compared after therapy. Results In both groups, the mean levels of aspartate aminotransferase/alanine aminotransferase, alkaline phosphatase, γ- glutamyl transpeptidase, bilirubin, and prothrombin time were significantly improved after 7 days of abstinence. In the probiotics group (baseline and after), albumin (3.5 ± 0.7 and 3.7 ± 0.6 g/dl, P=0.038) and tumor necrosis factor-α (121 ± 244 and 71 ± 123 pg/ml, P= 0.047) showed differences. In addition, the number of colony-forming units of Escherichia coli was significantly reduced (435 ± 287 and 168 ± 210, P= 0.002). In the placebo group, the level of LPS (1.7 ± 2.8 and 2.0 ± 2.7 EU/ml) was significantly increased. In the intergroup comparison, significant differences in the levels of tumor necrosis factor-α (P=0.042) and LPS (P =0.028) were observed between the groups. Conclusion Immediate abstinence is the most important treatment for patients with AH. In addition, 7 days of oral supplementation with cultured L. subtilis/S. faecium was associated with restoration of bowel flora and improvement of LPS in patients with AH.

Original languageEnglish
Pages (from-to)1300-1306
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Volume27
Issue number11
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Alcoholic Hepatitis
Enterococcus faecium
Probiotics
Lactobacillus
Multicenter Studies
Lipopolysaccharides
Placebos
Therapeutics
Stem Cells
Tumor Necrosis Factor-alpha
gamma-Glutamyltransferase
Liver Function Tests
Prothrombin Time
Therapeutic Uses
Aspartate Aminotransferases
Alanine Transaminase
Bilirubin
Alkaline Phosphatase
Albumins
Alcohols

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Han, Sang Hak ; Suk, Ki Tae ; Kim, Dong Joon ; Kim, Moonyoung ; Baik, Soonkoo ; Kim, Young Don ; Cheon, Gab Jin ; Choi, Dae Hee ; Ham, Young Lim ; Shin, Dong Hoon ; Kim, Eun Ji. / Effects of probiotics (cultured Lactobacillus subtilis/ Streptococcus faecium) in the treatment of alcoholic hepatitis : Randomized-controlled multicenter study. In: European Journal of Gastroenterology and Hepatology. 2015 ; Vol. 27, No. 11. pp. 1300-1306.
@article{a98cfbc93a92489e9488ec073a7f4810,
title = "Effects of probiotics (cultured Lactobacillus subtilis/ Streptococcus faecium) in the treatment of alcoholic hepatitis: Randomized-controlled multicenter study",
abstract = "Background Probiotics might reduce gut-derived microbial lipopolysaccharide (LPS) by restoring bowel flora in patients with alcoholic hepatitis (AH). We evaluated the therapeutic effects of probiotics in patients with AH. Patients and methods Between September 2010 and April 2012, 117 patients (probiotics 60 and placebo 57) were prospectively randomized to receive the 7 days of cultured Lactobacillus subtilis/Streptococcus faecium (1500 mg/day) or placebo. All patients were hospitalized and were not permitted to consume alcohol for the 7 days of the study. Liver function test, proinflammatory cytokines, LPS, and colony-forming units by stool culture were examined and compared after therapy. Results In both groups, the mean levels of aspartate aminotransferase/alanine aminotransferase, alkaline phosphatase, γ- glutamyl transpeptidase, bilirubin, and prothrombin time were significantly improved after 7 days of abstinence. In the probiotics group (baseline and after), albumin (3.5 ± 0.7 and 3.7 ± 0.6 g/dl, P=0.038) and tumor necrosis factor-α (121 ± 244 and 71 ± 123 pg/ml, P= 0.047) showed differences. In addition, the number of colony-forming units of Escherichia coli was significantly reduced (435 ± 287 and 168 ± 210, P= 0.002). In the placebo group, the level of LPS (1.7 ± 2.8 and 2.0 ± 2.7 EU/ml) was significantly increased. In the intergroup comparison, significant differences in the levels of tumor necrosis factor-α (P=0.042) and LPS (P =0.028) were observed between the groups. Conclusion Immediate abstinence is the most important treatment for patients with AH. In addition, 7 days of oral supplementation with cultured L. subtilis/S. faecium was associated with restoration of bowel flora and improvement of LPS in patients with AH.",
author = "Han, {Sang Hak} and Suk, {Ki Tae} and Kim, {Dong Joon} and Moonyoung Kim and Soonkoo Baik and Kim, {Young Don} and Cheon, {Gab Jin} and Choi, {Dae Hee} and Ham, {Young Lim} and Shin, {Dong Hoon} and Kim, {Eun Ji}",
year = "2015",
month = "10",
day = "1",
doi = "10.1097/MEG.0000000000000458",
language = "English",
volume = "27",
pages = "1300--1306",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

Effects of probiotics (cultured Lactobacillus subtilis/ Streptococcus faecium) in the treatment of alcoholic hepatitis : Randomized-controlled multicenter study. / Han, Sang Hak; Suk, Ki Tae; Kim, Dong Joon; Kim, Moonyoung; Baik, Soonkoo; Kim, Young Don; Cheon, Gab Jin; Choi, Dae Hee; Ham, Young Lim; Shin, Dong Hoon; Kim, Eun Ji.

In: European Journal of Gastroenterology and Hepatology, Vol. 27, No. 11, 01.10.2015, p. 1300-1306.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of probiotics (cultured Lactobacillus subtilis/ Streptococcus faecium) in the treatment of alcoholic hepatitis

T2 - Randomized-controlled multicenter study

AU - Han, Sang Hak

AU - Suk, Ki Tae

AU - Kim, Dong Joon

AU - Kim, Moonyoung

AU - Baik, Soonkoo

AU - Kim, Young Don

AU - Cheon, Gab Jin

AU - Choi, Dae Hee

AU - Ham, Young Lim

AU - Shin, Dong Hoon

AU - Kim, Eun Ji

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background Probiotics might reduce gut-derived microbial lipopolysaccharide (LPS) by restoring bowel flora in patients with alcoholic hepatitis (AH). We evaluated the therapeutic effects of probiotics in patients with AH. Patients and methods Between September 2010 and April 2012, 117 patients (probiotics 60 and placebo 57) were prospectively randomized to receive the 7 days of cultured Lactobacillus subtilis/Streptococcus faecium (1500 mg/day) or placebo. All patients were hospitalized and were not permitted to consume alcohol for the 7 days of the study. Liver function test, proinflammatory cytokines, LPS, and colony-forming units by stool culture were examined and compared after therapy. Results In both groups, the mean levels of aspartate aminotransferase/alanine aminotransferase, alkaline phosphatase, γ- glutamyl transpeptidase, bilirubin, and prothrombin time were significantly improved after 7 days of abstinence. In the probiotics group (baseline and after), albumin (3.5 ± 0.7 and 3.7 ± 0.6 g/dl, P=0.038) and tumor necrosis factor-α (121 ± 244 and 71 ± 123 pg/ml, P= 0.047) showed differences. In addition, the number of colony-forming units of Escherichia coli was significantly reduced (435 ± 287 and 168 ± 210, P= 0.002). In the placebo group, the level of LPS (1.7 ± 2.8 and 2.0 ± 2.7 EU/ml) was significantly increased. In the intergroup comparison, significant differences in the levels of tumor necrosis factor-α (P=0.042) and LPS (P =0.028) were observed between the groups. Conclusion Immediate abstinence is the most important treatment for patients with AH. In addition, 7 days of oral supplementation with cultured L. subtilis/S. faecium was associated with restoration of bowel flora and improvement of LPS in patients with AH.

AB - Background Probiotics might reduce gut-derived microbial lipopolysaccharide (LPS) by restoring bowel flora in patients with alcoholic hepatitis (AH). We evaluated the therapeutic effects of probiotics in patients with AH. Patients and methods Between September 2010 and April 2012, 117 patients (probiotics 60 and placebo 57) were prospectively randomized to receive the 7 days of cultured Lactobacillus subtilis/Streptococcus faecium (1500 mg/day) or placebo. All patients were hospitalized and were not permitted to consume alcohol for the 7 days of the study. Liver function test, proinflammatory cytokines, LPS, and colony-forming units by stool culture were examined and compared after therapy. Results In both groups, the mean levels of aspartate aminotransferase/alanine aminotransferase, alkaline phosphatase, γ- glutamyl transpeptidase, bilirubin, and prothrombin time were significantly improved after 7 days of abstinence. In the probiotics group (baseline and after), albumin (3.5 ± 0.7 and 3.7 ± 0.6 g/dl, P=0.038) and tumor necrosis factor-α (121 ± 244 and 71 ± 123 pg/ml, P= 0.047) showed differences. In addition, the number of colony-forming units of Escherichia coli was significantly reduced (435 ± 287 and 168 ± 210, P= 0.002). In the placebo group, the level of LPS (1.7 ± 2.8 and 2.0 ± 2.7 EU/ml) was significantly increased. In the intergroup comparison, significant differences in the levels of tumor necrosis factor-α (P=0.042) and LPS (P =0.028) were observed between the groups. Conclusion Immediate abstinence is the most important treatment for patients with AH. In addition, 7 days of oral supplementation with cultured L. subtilis/S. faecium was associated with restoration of bowel flora and improvement of LPS in patients with AH.

UR - http://www.scopus.com/inward/record.url?scp=84942791105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942791105&partnerID=8YFLogxK

U2 - 10.1097/MEG.0000000000000458

DO - 10.1097/MEG.0000000000000458

M3 - Article

VL - 27

SP - 1300

EP - 1306

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 11

ER -