Effects of radiofrequency catheter ablation for premature ventricular complexes originating from the right ventricular outflow tract on right ventricular function

Jae Sun Uhm, Kyu Yong Ko, Chi Young Shim, Je Wook Park, Minkwan Kim, Sung A. Bae, In Hyun Jung, In Soo Kim, Jong Youn Kim, Eui Young Choi, Won Jeong Son, Yun Ho Roh, Hee Tae Yu, Tae Hoon Kim, Geu Ru Hong, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: This study aimed to elucidate the relationship between premature ventricular complexes (PVCs) and right ventricular (RV) dysfunction, and the effects of radiofrequency catheter ablation (RFCA) on RV function. Methods: A total of 110 patients (age, 50.8 ± 14.4 years; 30 men) without structural heart disease who had undergone RFCA for RV outflow tract (RVOT) PVCs were retrospectively included. RV function was assessed using fractional area change (FAC) and global longitudinal strain (GLS) before and after RFCA. Clinical data were compared between the RV dysfunction (n = 63) and preserved RV function (n = 47) groups. The relationship between PVC burden and RV function was analyzed. Change in RV function before and after RFCA was compared between patients with successful and failed RFCA. Results: PVC burden was significantly higher in the RV dysfunction group than in the preserved RV function group (p <.001). FAC and GLS were significantly worse in proportion to PVC burden (p <.001 and p <.001, respectively). The risk factor associated with RV dysfunction was PVC burden [odds ratio (95% confidence interval), 1.092 (1.052–1.134); p <.001]. Improvement in FAC (13.0 ± 8.7% and –2.5 ± 5.6%, respectively; p <.001) and GLS (–6.8 ± 5.7% and 2.1 ± 4.2%, respectively; p <.001) was significant in the patients with successful RFCA, compared to the patients in whom RFCA failed. Conclusions: Frequent RVOT PVCs are associated with RV dysfunction. RV dysfunction is reversible by successful RFCA.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalJournal of Cardiovascular Electrophysiology
Volume34
Issue number1
DOIs
Publication statusPublished - 2023 Jan

Bibliographical note

Funding Information:
This study was not supported by any grant.

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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