Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis

Jeong Seok Choi, Seong Bin Hong, In Young Hyun, JaeYoul Lim, Young Mo Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The aim of this prospective study was to investigate the effect of salivary stimulation therapy using pilocarpine (a cholinergic agent) on chronic radioactive iodine (RAI)-induced sialadenitis. Methods: Sixty-one patients with a diagnosis of chronic RAI-induced sialadenitis after thyroidectomy and RAI therapy were enrolled in this prospective study. Patients received salivary stimulation therapy with pilocarpine (5 mg, 3 times daily) over a 3-month period. Subjective symptom scores were assessed using self-reported questionnaires. Salivary flow rates (SFRs) were measured and salivary gland scintigraphy (SGS) was performed to evaluate objective salivary gland functions. Results: After salivary stimulation therapy, subjective symptom scores were significantly improved (p=0.002), but posttreatment unstimulated and stimulated SFRs did not differ significantly from pretreatment values. SGS parameters, that is, uptake ratio (UR), maximum accumulation (MA), Tmin, and maximum secretion (MS) of parotid and submandibular glands were nonsignificantly different after salivary stimulation therapy. Conclusion: The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration.

Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalThyroid
Volume25
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Sialadenitis
Iodine
Salivary Glands
Pilocarpine
Radionuclide Imaging
Therapeutics
Prospective Studies
Submandibular Gland
Parotid Gland
Thyroidectomy
Cholinergic Agents

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Choi, Jeong Seok ; Hong, Seong Bin ; Hyun, In Young ; Lim, JaeYoul ; Kim, Young Mo. / Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis. In: Thyroid. 2015 ; Vol. 25, No. 7. pp. 839-845.
@article{8aacc342177c4372becf94b2ca657c0b,
title = "Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis",
abstract = "Background: The aim of this prospective study was to investigate the effect of salivary stimulation therapy using pilocarpine (a cholinergic agent) on chronic radioactive iodine (RAI)-induced sialadenitis. Methods: Sixty-one patients with a diagnosis of chronic RAI-induced sialadenitis after thyroidectomy and RAI therapy were enrolled in this prospective study. Patients received salivary stimulation therapy with pilocarpine (5 mg, 3 times daily) over a 3-month period. Subjective symptom scores were assessed using self-reported questionnaires. Salivary flow rates (SFRs) were measured and salivary gland scintigraphy (SGS) was performed to evaluate objective salivary gland functions. Results: After salivary stimulation therapy, subjective symptom scores were significantly improved (p=0.002), but posttreatment unstimulated and stimulated SFRs did not differ significantly from pretreatment values. SGS parameters, that is, uptake ratio (UR), maximum accumulation (MA), Tmin, and maximum secretion (MS) of parotid and submandibular glands were nonsignificantly different after salivary stimulation therapy. Conclusion: The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration.",
author = "Choi, {Jeong Seok} and Hong, {Seong Bin} and Hyun, {In Young} and JaeYoul Lim and Kim, {Young Mo}",
year = "2015",
month = "7",
day = "1",
doi = "10.1089/thy.2014.0525",
language = "English",
volume = "25",
pages = "839--845",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis. / Choi, Jeong Seok; Hong, Seong Bin; Hyun, In Young; Lim, JaeYoul; Kim, Young Mo.

In: Thyroid, Vol. 25, No. 7, 01.07.2015, p. 839-845.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis

AU - Choi, Jeong Seok

AU - Hong, Seong Bin

AU - Hyun, In Young

AU - Lim, JaeYoul

AU - Kim, Young Mo

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: The aim of this prospective study was to investigate the effect of salivary stimulation therapy using pilocarpine (a cholinergic agent) on chronic radioactive iodine (RAI)-induced sialadenitis. Methods: Sixty-one patients with a diagnosis of chronic RAI-induced sialadenitis after thyroidectomy and RAI therapy were enrolled in this prospective study. Patients received salivary stimulation therapy with pilocarpine (5 mg, 3 times daily) over a 3-month period. Subjective symptom scores were assessed using self-reported questionnaires. Salivary flow rates (SFRs) were measured and salivary gland scintigraphy (SGS) was performed to evaluate objective salivary gland functions. Results: After salivary stimulation therapy, subjective symptom scores were significantly improved (p=0.002), but posttreatment unstimulated and stimulated SFRs did not differ significantly from pretreatment values. SGS parameters, that is, uptake ratio (UR), maximum accumulation (MA), Tmin, and maximum secretion (MS) of parotid and submandibular glands were nonsignificantly different after salivary stimulation therapy. Conclusion: The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration.

AB - Background: The aim of this prospective study was to investigate the effect of salivary stimulation therapy using pilocarpine (a cholinergic agent) on chronic radioactive iodine (RAI)-induced sialadenitis. Methods: Sixty-one patients with a diagnosis of chronic RAI-induced sialadenitis after thyroidectomy and RAI therapy were enrolled in this prospective study. Patients received salivary stimulation therapy with pilocarpine (5 mg, 3 times daily) over a 3-month period. Subjective symptom scores were assessed using self-reported questionnaires. Salivary flow rates (SFRs) were measured and salivary gland scintigraphy (SGS) was performed to evaluate objective salivary gland functions. Results: After salivary stimulation therapy, subjective symptom scores were significantly improved (p=0.002), but posttreatment unstimulated and stimulated SFRs did not differ significantly from pretreatment values. SGS parameters, that is, uptake ratio (UR), maximum accumulation (MA), Tmin, and maximum secretion (MS) of parotid and submandibular glands were nonsignificantly different after salivary stimulation therapy. Conclusion: The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration.

UR - http://www.scopus.com/inward/record.url?scp=84936943399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84936943399&partnerID=8YFLogxK

U2 - 10.1089/thy.2014.0525

DO - 10.1089/thy.2014.0525

M3 - Article

C2 - 25809840

AN - SCOPUS:84936943399

VL - 25

SP - 839

EP - 845

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 7

ER -