Effects of Topical Antiglaucoma Application on Conjunctival Impression Cytology Specimens

Samin Hong, Christopher Seungkyu Lee, KyoungYul Seo, Gong Je Seong, Young Jae Hong

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Purpose: To evaluate the changes in conjunctival impression cytology specimens from patients receiving various topical antiglaucoma medications. Design: Cross-sectional comparative study. Methods: Impression cytology specimens were obtained from the eyes taking no topical medication (n = 20) and from the eyes taking various antiglaucoma medications (timolol n = 34; latanoprost n = 40; dorzolamide n = 32; timolol + latanoprost n = 30; timolol + dorzolamide n = 34). Specimens were graded on a scale of zero to three according to Nelson's method. Results: Cytology scores were significantly higher in the medication group than the control group. Mean cytology scores of the control, timolol, latanoprost, dorzolamide, timolol + latanoprost, and timolol + dorzolamide group were 0.20, 1.62, 2.00, 1.75, 2.13, and 2.44, respectively. Among the medication groups, cytology scores were significantly lower in the monotherapy group than the fixed-combination therapy group. Conclusions: Various topical antiglaucoma medications induce a significant degree of squamous metaplasia. Conjunctival surface could be altered after the long-term use of antiglaucoma medication.

Original languageEnglish
Pages (from-to)185-186
Number of pages2
JournalAmerican Journal of Ophthalmology
Volume142
Issue number1
DOIs
Publication statusPublished - 2006 Jul 1

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latanoprost
dorzolamide
Timolol
Cell Biology
Metaplasia
Group Psychotherapy
Cross-Sectional Studies
Control Groups

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Hong, Samin ; Lee, Christopher Seungkyu ; Seo, KyoungYul ; Seong, Gong Je ; Hong, Young Jae. / Effects of Topical Antiglaucoma Application on Conjunctival Impression Cytology Specimens. In: American Journal of Ophthalmology. 2006 ; Vol. 142, No. 1. pp. 185-186.
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abstract = "Purpose: To evaluate the changes in conjunctival impression cytology specimens from patients receiving various topical antiglaucoma medications. Design: Cross-sectional comparative study. Methods: Impression cytology specimens were obtained from the eyes taking no topical medication (n = 20) and from the eyes taking various antiglaucoma medications (timolol n = 34; latanoprost n = 40; dorzolamide n = 32; timolol + latanoprost n = 30; timolol + dorzolamide n = 34). Specimens were graded on a scale of zero to three according to Nelson's method. Results: Cytology scores were significantly higher in the medication group than the control group. Mean cytology scores of the control, timolol, latanoprost, dorzolamide, timolol + latanoprost, and timolol + dorzolamide group were 0.20, 1.62, 2.00, 1.75, 2.13, and 2.44, respectively. Among the medication groups, cytology scores were significantly lower in the monotherapy group than the fixed-combination therapy group. Conclusions: Various topical antiglaucoma medications induce a significant degree of squamous metaplasia. Conjunctival surface could be altered after the long-term use of antiglaucoma medication.",
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Effects of Topical Antiglaucoma Application on Conjunctival Impression Cytology Specimens. / Hong, Samin; Lee, Christopher Seungkyu; Seo, KyoungYul; Seong, Gong Je; Hong, Young Jae.

In: American Journal of Ophthalmology, Vol. 142, No. 1, 01.07.2006, p. 185-186.

Research output: Contribution to journalArticle

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