Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment

Nam Su Ku, Jin Ok Oh, So Youn Shin, Sun Bean Kim, Hye Won Kim, Su Jin Jeong, Sang Hoon Han, Young Goo Song, June Myung Kim, Jun Yong Choi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The effects of tuberculosis (TB) on the kinetics of CD4+ T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4+ T cell counts and viral loads at the time of starting cART. We compared the rate of CD4+ T cell increase for 5 years after cART. The time to CD4 + T cell increase >250 cells/mm3 was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4+ T cell counts at 5 years after cART (p=0.048). The difference in CD4+ T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4+ T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume29
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

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