Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment

Nam Su Ku, Jin Ok Oh, So Youn Shin, Sun Bean Kim, Hye Won Kim, Su Jin Jeong, Sang Hoon Han, Young Goo Song, June Myung Kim, Jun Yong Choi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The effects of tuberculosis (TB) on the kinetics of CD4+ T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4+ T cell counts and viral loads at the time of starting cART. We compared the rate of CD4+ T cell increase for 5 years after cART. The time to CD4 + T cell increase >250 cells/mm3 was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4+ T cell counts at 5 years after cART (p=0.048). The difference in CD4+ T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4+ T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume29
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

Fingerprint

CD4 Lymphocyte Count
Tuberculosis
HIV
T-Lymphocytes
Therapeutics
Viral Load
Case-Control Studies
Immunity

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Ku, Nam Su ; Oh, Jin Ok ; Shin, So Youn ; Kim, Sun Bean ; Kim, Hye Won ; Jeong, Su Jin ; Han, Sang Hoon ; Song, Young Goo ; Kim, June Myung ; Choi, Jun Yong. / Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment. In: AIDS Research and Human Retroviruses. 2013 ; Vol. 29, No. 2. pp. 226-230.
@article{7635f2bbdd2041c1a1763a94e20350f0,
title = "Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment",
abstract = "The effects of tuberculosis (TB) on the kinetics of CD4+ T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4+ T cell counts and viral loads at the time of starting cART. We compared the rate of CD4+ T cell increase for 5 years after cART. The time to CD4 + T cell increase >250 cells/mm3 was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4+ T cell counts at 5 years after cART (p=0.048). The difference in CD4+ T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4+ T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.",
author = "Ku, {Nam Su} and Oh, {Jin Ok} and Shin, {So Youn} and Kim, {Sun Bean} and Kim, {Hye Won} and Jeong, {Su Jin} and Han, {Sang Hoon} and Song, {Young Goo} and Kim, {June Myung} and Choi, {Jun Yong}",
year = "2013",
month = "2",
day = "1",
doi = "10.1089/aid.2012.0192",
language = "English",
volume = "29",
pages = "226--230",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment. / Ku, Nam Su; Oh, Jin Ok; Shin, So Youn; Kim, Sun Bean; Kim, Hye Won; Jeong, Su Jin; Han, Sang Hoon; Song, Young Goo; Kim, June Myung; Choi, Jun Yong.

In: AIDS Research and Human Retroviruses, Vol. 29, No. 2, 01.02.2013, p. 226-230.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Effects of tuberculosis on the kinetics of CD4+ T cell count among HIV-infected patients who initiated antiretroviral therapy early after tuberculosis treatment

AU - Ku, Nam Su

AU - Oh, Jin Ok

AU - Shin, So Youn

AU - Kim, Sun Bean

AU - Kim, Hye Won

AU - Jeong, Su Jin

AU - Han, Sang Hoon

AU - Song, Young Goo

AU - Kim, June Myung

AU - Choi, Jun Yong

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The effects of tuberculosis (TB) on the kinetics of CD4+ T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4+ T cell counts and viral loads at the time of starting cART. We compared the rate of CD4+ T cell increase for 5 years after cART. The time to CD4 + T cell increase >250 cells/mm3 was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4+ T cell counts at 5 years after cART (p=0.048). The difference in CD4+ T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4+ T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.

AB - The effects of tuberculosis (TB) on the kinetics of CD4+ T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4+ T cell counts and viral loads at the time of starting cART. We compared the rate of CD4+ T cell increase for 5 years after cART. The time to CD4 + T cell increase >250 cells/mm3 was significantly slower in HIV-TB-coinfected patients (p=0.015, by log rank test). HIV-TB-coinfected patients had significantly lower median CD4+ T cell counts at 5 years after cART (p=0.048). The difference in CD4+ T cell increase was observed only during the first 6 months after cART initiation (p=0.002). These data suggest that TB slows the rate of CD4+ T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated.

UR - http://www.scopus.com/inward/record.url?scp=84872904751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872904751&partnerID=8YFLogxK

U2 - 10.1089/aid.2012.0192

DO - 10.1089/aid.2012.0192

M3 - Review article

C2 - 22881387

AN - SCOPUS:84872904751

VL - 29

SP - 226

EP - 230

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 2

ER -