Effects of vitamin and antioxidant supplements in prevention of bladder cancer: A meta-analysis of randomized controlled trials

So Jung Park, Seung Kwon Myung, Yunju Lee, Yong Jae Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92-1.17; I 2 = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00-2.09; I 2 = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.

Original languageEnglish
Pages (from-to)628-635
Number of pages8
JournalJournal of Korean medical science
Volume32
Issue number4
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Urinary Bladder Neoplasms
Vitamins
Meta-Analysis
Randomized Controlled Trials
Antioxidants
Confidence Intervals
beta Carotene
Control Groups
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{11a1346d7f304071b2c01cb66828e495,
title = "Effects of vitamin and antioxidant supplements in prevention of bladder cancer: A meta-analysis of randomized controlled trials",
abstract = "This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95{\%} confidence interval [CI] 0.92-1.17; I 2 = 39.7{\%}). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95{\%} CI 1.00-2.09; I 2 = 0.0{\%}; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.",
author = "Park, {So Jung} and Myung, {Seung Kwon} and Yunju Lee and Lee, {Yong Jae}",
year = "2017",
month = "1",
day = "1",
doi = "10.3346/jkms.2017.32.4.628",
language = "English",
volume = "32",
pages = "628--635",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "4",

}

Effects of vitamin and antioxidant supplements in prevention of bladder cancer : A meta-analysis of randomized controlled trials. / Park, So Jung; Myung, Seung Kwon; Lee, Yunju; Lee, Yong Jae.

In: Journal of Korean medical science, Vol. 32, No. 4, 01.01.2017, p. 628-635.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of vitamin and antioxidant supplements in prevention of bladder cancer

T2 - A meta-analysis of randomized controlled trials

AU - Park, So Jung

AU - Myung, Seung Kwon

AU - Lee, Yunju

AU - Lee, Yong Jae

PY - 2017/1/1

Y1 - 2017/1/1

N2 - This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92-1.17; I 2 = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00-2.09; I 2 = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.

AB - This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92-1.17; I 2 = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00-2.09; I 2 = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.

UR - http://www.scopus.com/inward/record.url?scp=85015252913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015252913&partnerID=8YFLogxK

U2 - 10.3346/jkms.2017.32.4.628

DO - 10.3346/jkms.2017.32.4.628

M3 - Article

C2 - 28244289

AN - SCOPUS:85015252913

VL - 32

SP - 628

EP - 635

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 4

ER -