Effects of vitamin and antioxidant supplements in prevention of bladder cancer: A meta-analysis of randomized controlled trials

So Jung Park, Seung Kwon Myung, Yunju Lee, Yong Jae Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)


This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92-1.17; I 2 = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00-2.09; I 2 = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.

Original languageEnglish
Pages (from-to)628-635
Number of pages8
JournalJournal of Korean medical science
Issue number4
Publication statusPublished - 2017 Jan 1


All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this