Effects of weight loss using supplementation with

Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals

Minkyung Kim, Minjoo Kim, Miso Kang, Hye Jin Yoo, Min Sun Kim, Young Tae Ahn, Jae Hun Sim, Sun Ha Jee, Jong Ho Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Our previous study showed that supplementation with a combination of Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032 reduced the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area in overweight subjects. We aimed to evaluate whether the changes in adiposity after supplementation with Lactobacillus strains were associated with metabolic intermediates. A randomized, double-blind, placebo-controlled study was conducted on 66 non-diabetic and overweight individuals. Over a 12-week period, the probiotic group consumed 2 g of probiotic powder, whereas the placebo group consumed the same product without the probiotics. To investigate metabolic alterations, we performed plasma metabolomics using ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS). Probiotic supplementation significantly increased the levels of octenoylcarnitine (C8:1), tetradecenoylcarnitine (C14:1), decanoylcarnitine (C10) and dodecenoylcarnitine (C12:1) compared with the levels from placebo supplementation. In the probiotic group, the changes in the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area were negatively associated with changes in the levels of C8:1, C14:1, C10 and C12:1 acylcarnitines. In overweight individuals, probiotic-induced weight loss and adiposity reduction from the probiotic supplementation were associated with an increase in medium-chain acylcarnitines.

Original languageEnglish
Pages (from-to)250-261
Number of pages12
JournalFood and Function
Volume8
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Probiotics
Lactobacillus
probiotics
body fat
Adipose Tissue
Weight Loss
weight loss
placebos
Subcutaneous Fat
Placebos
Adiposity
subcutaneous fat
adiposity
Lactobacillus curvatus
Lactobacillus plantarum
ultra-performance liquid chromatography
Body Weight Changes
Metabolomics
body weight changes
metabolomics

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Kim, Minkyung ; Kim, Minjoo ; Kang, Miso ; Yoo, Hye Jin ; Kim, Min Sun ; Ahn, Young Tae ; Sim, Jae Hun ; Jee, Sun Ha ; Lee, Jong Ho. / Effects of weight loss using supplementation with : Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals. In: Food and Function. 2017 ; Vol. 8, No. 1. pp. 250-261.
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Effects of weight loss using supplementation with : Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals. / Kim, Minkyung; Kim, Minjoo; Kang, Miso; Yoo, Hye Jin; Kim, Min Sun; Ahn, Young Tae; Sim, Jae Hun; Jee, Sun Ha; Lee, Jong Ho.

In: Food and Function, Vol. 8, No. 1, 01.01.2017, p. 250-261.

Research output: Contribution to journalArticle

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