Purpose: Ischemia-reperfusion injury is inevitable during donor organ harvest and recipient allograft reperfusion in kidney transplantation, and affects graft outcomes. Dexmedetomidine, an α2-adrenoreceptor agonist, has renoprotective effects against ischemia-reperfusion injury. We investigated the effects of intraoperative dexmedetomidine infusion on renal function and the development of delayed graft function after elective living donor kidney transplantation in a randomized controlled trial. Methods: A total of 104 patients were randomly assigned to receive either an intraoperative infusion of dexmedetomidine 0.4 μg·kg-1·hr-1 or 0.9% saline. The primary outcome was the serum creatinine level on postoperative day (POD) 7. Secondary outcomes were renal function and the degree of inflammation and included the following variables: serum creatinine level and estimated glomerular filtration rate up to six months; incidence of delayed graft function; and levels of serum cystatin C, plasma interleukin (IL)-1β, and IL-18 during the perioperative period. Results: The mean (standard deviation) serum creatinine level on POD 7 was comparable between the groups (dexmedetomidine vs control: 1.11 [0.87] mg·dL-1vs 1.06 [0.73] mg·dL-1; mean difference, 0.05; 95% confidence interval, -0.27 to 0.36; P = 0.77). Delayed graft function occurred in one patient in each group (odds ratio, 1.020; P > 0.99). There were no significant differences in the secondary outcomes between the groups (all P > 0.05). Conclusions: Intraoperative dexmedetomidine infusion did not produce any beneficial effects on renal function or delayed graft function in patients undergoing elective living donor kidney transplantation. Study registration: www.ClinicalTrials.gov (NCT03327389); registered 31 October 2017.
|Translated title of the contribution||Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial|
|Number of pages||12|
|Journal||Canadian Journal of Anesthesia|
|Publication status||Published - 2022 Apr|
Bibliographical noteFunding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Government of the Republic of Korea (Ministry of Science and ICT) (NRF-2017R1C1B5017937).
Conceptualization: Jin Ha Park , Bon-Nyeo Koo , Min-Soo Kim , and Young-Lan Kwak. Data curation: Jin Ha Park , Bon-Nyeo Koo , and Young-Lan Kwak. Project administration: Jin Ha Park , Bon-Nyeo Koo , Min-Soo Kim , and Young-Lan Kwak. Methodology: Jin Ha Park , Bon-Nyeo Koo , Dongkwan Shin , and Young-Lan Kwak. Investigation and formal analysis: Jin Ha Park , Bon-Nyeo Koo , and Young-Lan Kwak. Writing original draft: Jin Ha Park , Bon-Nyeo Koo , Min-Soo Kim , and Young-Lan Kwak. Writing review and editing: Jin Ha Park , Bon-Nyeo Koo , Min-Soo Kim , Dongkwan Shin , and Young-Lan Kwak. This study was presented in part as an abstract at the 97th Annual Scientific Meeting of the Korean Society of Anaesthesiologists, Incheon, South Korea, Nov 5-7, 2020. None. This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Government of the Republic of Korea (Ministry of Science and ICT) (NRF-2017R1C1B5017937). This submission was handled by Dr. Stephan K.W. Schwarz, Editor-in-Chief, Canadian Journal of Anesthesia/Journal canadien d?anesth?sie.
© 2021, Canadian Anesthesiologists' Society.
All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine