Efficacy and Safety of Gemigliptin in Post-Transplant Patients With Type 2 Diabetes Mellitus

Jaehyun Bae, Youjin Kim, Yongin Cho, Minyoung Lee, Ji Yeon Lee, Yong ho Lee, Byung Wan Lee, Bong Soo Cha, Dong Jin Joo, Kyu Ha Huh, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Gemigliptin is a potent, selective dipeptidyl peptidase (DPP)-4 inhibitor that does not require any dosage adjustment based on renal function. It is also known to have no apparent interaction with commonly used drugs. In the present study, we aimed to evaluate the glucose-lowering efficacy and safety of gemigliptin in post-transplant patients with type 2 diabetes mellitus (T2D). Methods: A total of 84 patients who were prescribed gemigliptin for more than 180 days after transplantation were analyzed retrospectively. Six-month changes in blood glucose and glycated hemoglobin (HbA1c) levels were checked to assess glycemic efficacy. Safety was evaluated by examining its influence on immunosuppressive treatment, as determined by the blood trough level and dosage of calcineurin inhibitors, as well as changes in parameters related to liver and renal function. Results: Six months of gemigliptin treatment significantly lowered blood glucose level (HbA1c: 8.16 ± 1.69 to 7.44 ± 1.26%; P <.001). There were no significant changes in blood trough levels of immunosuppressants, including tacrolimus, cyclosporine, and sirolimus. The dosage of immunosuppressants was also stable. In addition, there were no significant changes in the levels of liver enzymes and renal function during 6 months of treatment. Conclusion: Gemigliptin robustly lowered blood glucose levels without exerting any significant effect on immunosuppressive treatment, renal function, and liver enzymes in post-transplant patients with T2D.

Original languageEnglish
Pages (from-to)3444-3448
Number of pages5
JournalTransplantation Proceedings
Volume51
Issue number10
DOIs
Publication statusPublished - 2019 Dec

Bibliographical note

Funding Information:
This work was supported by the Yonsei University College of Medicine (7?2015?0339); the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. NRF-2019R1A2C2007514).

Publisher Copyright:
© 2019 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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