Efficacy and safety of pegylated interferon base treatment in patients with chronic hepatitis C on dialysis

Sang Bong Ahn, Dae Won Jun, Sang Gyune Kim, Sae Hwan Lee, Hyun Phil Shin, Won Hyeok Choe, Ja Kyung Kim, Kyu Sik Jung, Do Young Kim, Jae Jun Shim, Soo Young Park, Yeon Seok Seo, Won Kim, Jae Il Chung

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Abstract

Introduction: Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on dialysis are difficult to treat and show higher dropout rates during treatment. The aim of this study was to analyze the treatment outcomes in patients with CHC and underlying end-stage renal disease on dialysis in Korea. Methods: A retrospective multi-center study of 35 patients with CHC and underlying ESRD on regular dialysis from 13 centers were analyzed. We investigated the tolerability and efficacy of pegylated interferon therapy with or without ribavirin on dialysis patients. Results: Twenty patients (57%) were genotype 1. Sixteen patients (46%) were treated with pegylated interferon monotherapy. Nineteen patients (54%) were treated with pegylated interferon and ribavirin. The overall sustained virological response (SVR) rate was 65.7% in all subjects. Thirteen patients (37%) dropped out before completion of treatment, and six patients (46.2%) showed SVR despite premature termination of treatment. Twenty patients (90.9%) achieved SVR among the 22 patients who completed the scheduled course. The most common side effects were anemia and neutropenia. The patients receiving ribavirin treatment showed a higher dropout rate (52.6% vs. 18.8%, p = 0.04) and higher SVR rate (68.4% vs. 62.5%, p = 0.07) compared to the pegylated interferon mono-treatment group. Conclusions: The difficulty in treating HCV patients with ESRD was attributed to higher dropout rate. However, despite the high dropout rate (37%), the SVR rate in genotype 1 was 65% and in genotypes 2 and 3 was 66%. Patients who completed the treatment showed a high SVR rate of 89.5%.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalEuropean Journal of Internal Medicine
Volume26
Issue number4
DOIs
Publication statusPublished - 2015 May 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Ahn, S. B., Jun, D. W., Kim, S. G., Lee, S. H., Shin, H. P., Choe, W. H., Kim, J. K., Jung, K. S., Kim, D. Y., Shim, J. J., Park, S. Y., Seo, Y. S., Kim, W., & Chung, J. I. (2015). Efficacy and safety of pegylated interferon base treatment in patients with chronic hepatitis C on dialysis. European Journal of Internal Medicine, 26(4), 292-296. https://doi.org/10.1016/j.ejim.2015.03.011