Efficacy and safety of red ginseng extract powder in patients with erectile dysfunction: Multicenter, randomized, double-blind, placebo-controlled study

Won Sik Ham, Won Tae Kim, Jin Sun Lee, Hee Jeong Ju, Shin Jyung Kang, Jin Hwan Oh, Youl Her, Jae Yong Chung, Kwangsung Park, Young Deuk Choi

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the safety and efficacy of red ginseng extract powder (OKBT) for treating erectile dysfunction. Materials and Methods: Sixty-nine adult patients with mild to moderate erectile dysfunction of various etiologies were randomized to receive placebo or red ginseng extract powder. The red ginseng extract powder used in the present study was named OKBT. The primary efficacy parameter was response to the International Index of Erectile Function (IIEF) erectile function domain at baseline and week 8. Other IIEF domain scores were evaluated as secondary parameters. For safety evaluation, we performed history taking, physical examination, clinical laboratory tests, and hormonal tests at baseline and week 8. Results: There were no significant differences in the patients' characteristics between the 2 groups. After 8 weeks of administration, primary efficacy (erectile function domain) and all secondary efficacy domains were significantly improved in the OKBT group compared with the placebo group (p < 0.05). Notably, even the domain related to sexual desire, frequency and degree of sexual desire, was also improved in the OKBT group (p < 0.001). There were no significant adverse reactions with OKBT administration, and there were also no significant differences in the results of laboratory tests between the 2 groups after administration. Conclusions: Our data show that red ginseng extract powder can be used as an alternative remedy for Korean men suffering from mild to moderate erectile dysfunction.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalKorean Journal of Urology
Volume50
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1

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Panax
Erectile Dysfunction
Powders
Placebos
Safety
Physical Examination

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Ham, Won Sik ; Kim, Won Tae ; Lee, Jin Sun ; Ju, Hee Jeong ; Kang, Shin Jyung ; Oh, Jin Hwan ; Her, Youl ; Chung, Jae Yong ; Park, Kwangsung ; Choi, Young Deuk. / Efficacy and safety of red ginseng extract powder in patients with erectile dysfunction : Multicenter, randomized, double-blind, placebo-controlled study. In: Korean Journal of Urology. 2009 ; Vol. 50, No. 2. pp. 159-164.
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abstract = "Purpose: To evaluate the safety and efficacy of red ginseng extract powder (OKBT) for treating erectile dysfunction. Materials and Methods: Sixty-nine adult patients with mild to moderate erectile dysfunction of various etiologies were randomized to receive placebo or red ginseng extract powder. The red ginseng extract powder used in the present study was named OKBT. The primary efficacy parameter was response to the International Index of Erectile Function (IIEF) erectile function domain at baseline and week 8. Other IIEF domain scores were evaluated as secondary parameters. For safety evaluation, we performed history taking, physical examination, clinical laboratory tests, and hormonal tests at baseline and week 8. Results: There were no significant differences in the patients' characteristics between the 2 groups. After 8 weeks of administration, primary efficacy (erectile function domain) and all secondary efficacy domains were significantly improved in the OKBT group compared with the placebo group (p < 0.05). Notably, even the domain related to sexual desire, frequency and degree of sexual desire, was also improved in the OKBT group (p < 0.001). There were no significant adverse reactions with OKBT administration, and there were also no significant differences in the results of laboratory tests between the 2 groups after administration. Conclusions: Our data show that red ginseng extract powder can be used as an alternative remedy for Korean men suffering from mild to moderate erectile dysfunction.",
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Efficacy and safety of red ginseng extract powder in patients with erectile dysfunction : Multicenter, randomized, double-blind, placebo-controlled study. / Ham, Won Sik; Kim, Won Tae; Lee, Jin Sun; Ju, Hee Jeong; Kang, Shin Jyung; Oh, Jin Hwan; Her, Youl; Chung, Jae Yong; Park, Kwangsung; Choi, Young Deuk.

In: Korean Journal of Urology, Vol. 50, No. 2, 01.02.2009, p. 159-164.

Research output: Contribution to journalArticle

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T1 - Efficacy and safety of red ginseng extract powder in patients with erectile dysfunction

T2 - Multicenter, randomized, double-blind, placebo-controlled study

AU - Ham, Won Sik

AU - Kim, Won Tae

AU - Lee, Jin Sun

AU - Ju, Hee Jeong

AU - Kang, Shin Jyung

AU - Oh, Jin Hwan

AU - Her, Youl

AU - Chung, Jae Yong

AU - Park, Kwangsung

AU - Choi, Young Deuk

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N2 - Purpose: To evaluate the safety and efficacy of red ginseng extract powder (OKBT) for treating erectile dysfunction. Materials and Methods: Sixty-nine adult patients with mild to moderate erectile dysfunction of various etiologies were randomized to receive placebo or red ginseng extract powder. The red ginseng extract powder used in the present study was named OKBT. The primary efficacy parameter was response to the International Index of Erectile Function (IIEF) erectile function domain at baseline and week 8. Other IIEF domain scores were evaluated as secondary parameters. For safety evaluation, we performed history taking, physical examination, clinical laboratory tests, and hormonal tests at baseline and week 8. Results: There were no significant differences in the patients' characteristics between the 2 groups. After 8 weeks of administration, primary efficacy (erectile function domain) and all secondary efficacy domains were significantly improved in the OKBT group compared with the placebo group (p < 0.05). Notably, even the domain related to sexual desire, frequency and degree of sexual desire, was also improved in the OKBT group (p < 0.001). There were no significant adverse reactions with OKBT administration, and there were also no significant differences in the results of laboratory tests between the 2 groups after administration. Conclusions: Our data show that red ginseng extract powder can be used as an alternative remedy for Korean men suffering from mild to moderate erectile dysfunction.

AB - Purpose: To evaluate the safety and efficacy of red ginseng extract powder (OKBT) for treating erectile dysfunction. Materials and Methods: Sixty-nine adult patients with mild to moderate erectile dysfunction of various etiologies were randomized to receive placebo or red ginseng extract powder. The red ginseng extract powder used in the present study was named OKBT. The primary efficacy parameter was response to the International Index of Erectile Function (IIEF) erectile function domain at baseline and week 8. Other IIEF domain scores were evaluated as secondary parameters. For safety evaluation, we performed history taking, physical examination, clinical laboratory tests, and hormonal tests at baseline and week 8. Results: There were no significant differences in the patients' characteristics between the 2 groups. After 8 weeks of administration, primary efficacy (erectile function domain) and all secondary efficacy domains were significantly improved in the OKBT group compared with the placebo group (p < 0.05). Notably, even the domain related to sexual desire, frequency and degree of sexual desire, was also improved in the OKBT group (p < 0.001). There were no significant adverse reactions with OKBT administration, and there were also no significant differences in the results of laboratory tests between the 2 groups after administration. Conclusions: Our data show that red ginseng extract powder can be used as an alternative remedy for Korean men suffering from mild to moderate erectile dysfunction.

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