Efficacy of biodegradable microneedle patches on periorbital wrinkles

Jihun Park, Jimyung Seo, Jung U. Shin, Do Hyeon Jeong, Jung Dong Kim, Kwang Hoon Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods.

Objective: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement.

Methods: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, comeometer, cutometer, and mexameter, respectively (CourageandKhazaka, Cologne, Germany).

Results: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and comeometer result with statistically significant differences. No significant side effects were noticed. Conclusion: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.

Original languageEnglish
Pages (from-to)597-607
Number of pages11
JournalKorean Journal of Dermatology
Volume52
Issue number9
Publication statusPublished - 2014 Jan 1

Fingerprint

Hyaluronic Acid
Epidermal Growth Factor
Patient Satisfaction
Double-Blind Method
Germany
Technology
Skin
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Park, J., Seo, J., Shin, J. U., Jeong, D. H., Kim, J. D., & Lee, K. H. (2014). Efficacy of biodegradable microneedle patches on periorbital wrinkles. Korean Journal of Dermatology, 52(9), 597-607.
Park, Jihun ; Seo, Jimyung ; Shin, Jung U. ; Jeong, Do Hyeon ; Kim, Jung Dong ; Lee, Kwang Hoon. / Efficacy of biodegradable microneedle patches on periorbital wrinkles. In: Korean Journal of Dermatology. 2014 ; Vol. 52, No. 9. pp. 597-607.
@article{8a99fb7f2f174ad9a482154295ece3ea,
title = "Efficacy of biodegradable microneedle patches on periorbital wrinkles",
abstract = "Background: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods.Objective: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement.Methods: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, comeometer, cutometer, and mexameter, respectively (CourageandKhazaka, Cologne, Germany).Results: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and comeometer result with statistically significant differences. No significant side effects were noticed. Conclusion: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.",
author = "Jihun Park and Jimyung Seo and Shin, {Jung U.} and Jeong, {Do Hyeon} and Kim, {Jung Dong} and Lee, {Kwang Hoon}",
year = "2014",
month = "1",
day = "1",
language = "English",
volume = "52",
pages = "597--607",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
publisher = "Korean Dermatological Association",
number = "9",

}

Park, J, Seo, J, Shin, JU, Jeong, DH, Kim, JD & Lee, KH 2014, 'Efficacy of biodegradable microneedle patches on periorbital wrinkles', Korean Journal of Dermatology, vol. 52, no. 9, pp. 597-607.

Efficacy of biodegradable microneedle patches on periorbital wrinkles. / Park, Jihun; Seo, Jimyung; Shin, Jung U.; Jeong, Do Hyeon; Kim, Jung Dong; Lee, Kwang Hoon.

In: Korean Journal of Dermatology, Vol. 52, No. 9, 01.01.2014, p. 597-607.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy of biodegradable microneedle patches on periorbital wrinkles

AU - Park, Jihun

AU - Seo, Jimyung

AU - Shin, Jung U.

AU - Jeong, Do Hyeon

AU - Kim, Jung Dong

AU - Lee, Kwang Hoon

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods.Objective: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement.Methods: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, comeometer, cutometer, and mexameter, respectively (CourageandKhazaka, Cologne, Germany).Results: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and comeometer result with statistically significant differences. No significant side effects were noticed. Conclusion: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.

AB - Background: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods.Objective: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement.Methods: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, comeometer, cutometer, and mexameter, respectively (CourageandKhazaka, Cologne, Germany).Results: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and comeometer result with statistically significant differences. No significant side effects were noticed. Conclusion: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.

UR - http://www.scopus.com/inward/record.url?scp=84908672790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908672790&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 597

EP - 607

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 9

ER -

Park J, Seo J, Shin JU, Jeong DH, Kim JD, Lee KH. Efficacy of biodegradable microneedle patches on periorbital wrinkles. Korean Journal of Dermatology. 2014 Jan 1;52(9):597-607.