Efficacy of fractional microneedle radiofrequency device in the treatment of primary axillary hyperhidrosis

A pilot study

Miri Kim, Jae Yong Shin, Jungsoo Lee, Ji Young Kim, SangHo Oh

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Fractional microneedle radiofrequency (FMR) devices deliver energy to the deep dermis through insulated microneedles without destroying the epidermis. These FMR devices have been shown to be effective for the treatment of wrinkles, acne scars and large pores. In this study it was postulated that FMR energy could specifically affect the sweat glands, preserving the skin surface even if sweat glands were seated in the deep dermis. Objective: To evaluate the efficacy and safety of FMR for primary axillary hyperhidrosis (PAH) treatment and to conduct a histological analysis before and after treatment. Methods: Twenty patients with PAH had 2 sessions of bipolar FMR treatment at 4-week intervals. Clinical improvement was evaluated using a Hyperhidrosis Disease Severity Scale (HDSS) and photographs were taken using the starch-iodine test at every visit and 2 months after the last treatment. The amount of sweat reduction was indirectly assessed using a Tewameter™. Skin biopsies were obtained from 3 of the enrolled patients before and after treatment. The satisfaction and adverse reactions of the research participants were recorded at every follow-up visit. Results: HDSS scores decreased significantly from a baseline of 3.3 to 1.5 and 1.8 after the first and second months of posttreatment follow-up sessions, respectively (p < 0.001). In response to a subjective assessment at 1 month after the second treatment, 75% of patients (n = 15) had an HDSS score of 1 or 2, and 70% of patients (n = 14) expressed more than 50% improvement in their sweating. The starch-iodine reaction was also remarkably reduced in 95% of patients (n = 19) after FMR treatment. Histological findings showed a decrease in the number and size of both apocrine and eccrine glands 1 month after the final treatment. Side effects were minimal and included mild discomfort, transient swelling and postinflammatory hyperpigmentation. Conclusion: FMR treatment was effective for the treatment of PAH without significant adverse reactions due to direct volumetric heating of the lower dermis.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalDermatology
Volume227
Issue number3
DOIs
Publication statusPublished - 2013 Nov 1

Fingerprint

Hyperhidrosis
Equipment and Supplies
Dermis
Therapeutics
Sweat Glands
Iodine
Starch
Apocrine Glands
Eccrine Glands
Skin
Hyperpigmentation
Sweating
Sweat
Acne Vulgaris
Epidermis
Heating
Cicatrix

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, Miri ; Shin, Jae Yong ; Lee, Jungsoo ; Kim, Ji Young ; Oh, SangHo. / Efficacy of fractional microneedle radiofrequency device in the treatment of primary axillary hyperhidrosis : A pilot study. In: Dermatology. 2013 ; Vol. 227, No. 3. pp. 243-249.
@article{494dd6a762414adf83587e78253f022e,
title = "Efficacy of fractional microneedle radiofrequency device in the treatment of primary axillary hyperhidrosis: A pilot study",
abstract = "Background: Fractional microneedle radiofrequency (FMR) devices deliver energy to the deep dermis through insulated microneedles without destroying the epidermis. These FMR devices have been shown to be effective for the treatment of wrinkles, acne scars and large pores. In this study it was postulated that FMR energy could specifically affect the sweat glands, preserving the skin surface even if sweat glands were seated in the deep dermis. Objective: To evaluate the efficacy and safety of FMR for primary axillary hyperhidrosis (PAH) treatment and to conduct a histological analysis before and after treatment. Methods: Twenty patients with PAH had 2 sessions of bipolar FMR treatment at 4-week intervals. Clinical improvement was evaluated using a Hyperhidrosis Disease Severity Scale (HDSS) and photographs were taken using the starch-iodine test at every visit and 2 months after the last treatment. The amount of sweat reduction was indirectly assessed using a Tewameter™. Skin biopsies were obtained from 3 of the enrolled patients before and after treatment. The satisfaction and adverse reactions of the research participants were recorded at every follow-up visit. Results: HDSS scores decreased significantly from a baseline of 3.3 to 1.5 and 1.8 after the first and second months of posttreatment follow-up sessions, respectively (p < 0.001). In response to a subjective assessment at 1 month after the second treatment, 75{\%} of patients (n = 15) had an HDSS score of 1 or 2, and 70{\%} of patients (n = 14) expressed more than 50{\%} improvement in their sweating. The starch-iodine reaction was also remarkably reduced in 95{\%} of patients (n = 19) after FMR treatment. Histological findings showed a decrease in the number and size of both apocrine and eccrine glands 1 month after the final treatment. Side effects were minimal and included mild discomfort, transient swelling and postinflammatory hyperpigmentation. Conclusion: FMR treatment was effective for the treatment of PAH without significant adverse reactions due to direct volumetric heating of the lower dermis.",
author = "Miri Kim and Shin, {Jae Yong} and Jungsoo Lee and Kim, {Ji Young} and SangHo Oh",
year = "2013",
month = "11",
day = "1",
doi = "10.1159/000354602",
language = "English",
volume = "227",
pages = "243--249",
journal = "Dermatology",
issn = "1018-8665",
publisher = "S. Karger AG",
number = "3",

}

Efficacy of fractional microneedle radiofrequency device in the treatment of primary axillary hyperhidrosis : A pilot study. / Kim, Miri; Shin, Jae Yong; Lee, Jungsoo; Kim, Ji Young; Oh, SangHo.

In: Dermatology, Vol. 227, No. 3, 01.11.2013, p. 243-249.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy of fractional microneedle radiofrequency device in the treatment of primary axillary hyperhidrosis

T2 - A pilot study

AU - Kim, Miri

AU - Shin, Jae Yong

AU - Lee, Jungsoo

AU - Kim, Ji Young

AU - Oh, SangHo

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Background: Fractional microneedle radiofrequency (FMR) devices deliver energy to the deep dermis through insulated microneedles without destroying the epidermis. These FMR devices have been shown to be effective for the treatment of wrinkles, acne scars and large pores. In this study it was postulated that FMR energy could specifically affect the sweat glands, preserving the skin surface even if sweat glands were seated in the deep dermis. Objective: To evaluate the efficacy and safety of FMR for primary axillary hyperhidrosis (PAH) treatment and to conduct a histological analysis before and after treatment. Methods: Twenty patients with PAH had 2 sessions of bipolar FMR treatment at 4-week intervals. Clinical improvement was evaluated using a Hyperhidrosis Disease Severity Scale (HDSS) and photographs were taken using the starch-iodine test at every visit and 2 months after the last treatment. The amount of sweat reduction was indirectly assessed using a Tewameter™. Skin biopsies were obtained from 3 of the enrolled patients before and after treatment. The satisfaction and adverse reactions of the research participants were recorded at every follow-up visit. Results: HDSS scores decreased significantly from a baseline of 3.3 to 1.5 and 1.8 after the first and second months of posttreatment follow-up sessions, respectively (p < 0.001). In response to a subjective assessment at 1 month after the second treatment, 75% of patients (n = 15) had an HDSS score of 1 or 2, and 70% of patients (n = 14) expressed more than 50% improvement in their sweating. The starch-iodine reaction was also remarkably reduced in 95% of patients (n = 19) after FMR treatment. Histological findings showed a decrease in the number and size of both apocrine and eccrine glands 1 month after the final treatment. Side effects were minimal and included mild discomfort, transient swelling and postinflammatory hyperpigmentation. Conclusion: FMR treatment was effective for the treatment of PAH without significant adverse reactions due to direct volumetric heating of the lower dermis.

AB - Background: Fractional microneedle radiofrequency (FMR) devices deliver energy to the deep dermis through insulated microneedles without destroying the epidermis. These FMR devices have been shown to be effective for the treatment of wrinkles, acne scars and large pores. In this study it was postulated that FMR energy could specifically affect the sweat glands, preserving the skin surface even if sweat glands were seated in the deep dermis. Objective: To evaluate the efficacy and safety of FMR for primary axillary hyperhidrosis (PAH) treatment and to conduct a histological analysis before and after treatment. Methods: Twenty patients with PAH had 2 sessions of bipolar FMR treatment at 4-week intervals. Clinical improvement was evaluated using a Hyperhidrosis Disease Severity Scale (HDSS) and photographs were taken using the starch-iodine test at every visit and 2 months after the last treatment. The amount of sweat reduction was indirectly assessed using a Tewameter™. Skin biopsies were obtained from 3 of the enrolled patients before and after treatment. The satisfaction and adverse reactions of the research participants were recorded at every follow-up visit. Results: HDSS scores decreased significantly from a baseline of 3.3 to 1.5 and 1.8 after the first and second months of posttreatment follow-up sessions, respectively (p < 0.001). In response to a subjective assessment at 1 month after the second treatment, 75% of patients (n = 15) had an HDSS score of 1 or 2, and 70% of patients (n = 14) expressed more than 50% improvement in their sweating. The starch-iodine reaction was also remarkably reduced in 95% of patients (n = 19) after FMR treatment. Histological findings showed a decrease in the number and size of both apocrine and eccrine glands 1 month after the final treatment. Side effects were minimal and included mild discomfort, transient swelling and postinflammatory hyperpigmentation. Conclusion: FMR treatment was effective for the treatment of PAH without significant adverse reactions due to direct volumetric heating of the lower dermis.

UR - http://www.scopus.com/inward/record.url?scp=84890127896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890127896&partnerID=8YFLogxK

U2 - 10.1159/000354602

DO - 10.1159/000354602

M3 - Article

VL - 227

SP - 243

EP - 249

JO - Dermatology

JF - Dermatology

SN - 1018-8665

IS - 3

ER -