Efficacy of immunohistochemical staining in differentiating a squamous cell carcinoma in poorly differentiated rectal cancer

Two case reports

Sairafi Rami, Yoon Dae Han, Mi Jang, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Namkyu Kim

Research output: Contribution to journalArticle

Abstract

A rectal carcinoma, including primary an adenosquamous and a squamous cell carcinoma (SCC), is a very rare disease, accounting for 0.025% to 0.20% of all large-bowel malignant tumors. Because SCCs have a higher mortality than adenosquamous carcinomas, determining whether the primary rectal cancer exhibits an adenomatous component or a squamous component is important. While differentiating between these 2 components, especially in poorly differentiated rectal cancer, is difficult, specific immunohistochemical stains enable accurate diagnoses. Here, we report the use of immunohistochemical stains to distinguish between the adenomatous and the squamous components in 2 patients with low rectal cancer, a 58-year-old man and a 73-year-old woman, who were initially diagnosed using the histopathologic results for a poorly differentiated carcinoma. These data suggest that using these immunohistochemical stains will help to accurately diagnose the type of rectal cancer, especially for poorly differentiated carcinomas, and will provide important information to determine the proper treatment for the patient.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalAnnals of Coloproctology
Volume32
Issue number4
DOIs
Publication statusPublished - 2016 Aug 1

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Rectal Neoplasms
Squamous Cell Carcinoma
Staining and Labeling
Coloring Agents
Carcinoma
Adenosquamous Carcinoma
Rare Diseases
Mortality
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Rami, Sairafi ; Han, Yoon Dae ; Jang, Mi ; Cho, Min Soo ; Hur, Hyuk ; Min, Byung Soh ; Lee, Kang Young ; Kim, Namkyu. / Efficacy of immunohistochemical staining in differentiating a squamous cell carcinoma in poorly differentiated rectal cancer : Two case reports. In: Annals of Coloproctology. 2016 ; Vol. 32, No. 4. pp. 150-155.
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Efficacy of immunohistochemical staining in differentiating a squamous cell carcinoma in poorly differentiated rectal cancer : Two case reports. / Rami, Sairafi; Han, Yoon Dae; Jang, Mi; Cho, Min Soo; Hur, Hyuk; Min, Byung Soh; Lee, Kang Young; Kim, Namkyu.

In: Annals of Coloproctology, Vol. 32, No. 4, 01.08.2016, p. 150-155.

Research output: Contribution to journalArticle

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