Efficacy of infliximab in intestinal Behçet's disease: A Korean multicenter retrospective study

Jin Ha Lee, Jae Hee Cheon, Seong Woo Jeon, Byong Duk Ye, Suk Kyun Yang, Young Ho Kim, Kang Moon Lee, Jong Pil Im, Joo Sung Kim, Chang Kyun Lee, Hyo Jong Kim, Eun Young Kim, Kyeong Ok Kim, Byung Ik Jang, Won Ho Kim

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Abstract

Background: Although infliximab is widely accepted as a therapeutic option for inflammatory bowel disease, its therapeutic efficacy for the treatment of intestinal Behçet's disease (BD) is unknown. We investigated the short-term and long-term response rates to infliximab in intestinal BD and predictive factors of sustained treatment response following infliximab treatment. Methods: This study was conducted using a retrospective noncontrolled review of medical records from 8 tertiary hospitals in Korea. We collected clinical, demographic, and laboratory data for patients with 28 patients with intestinal BD who received at least 1 dose of infliximab. Response rates of infliximab at 2, 4, 30, and 54 weeks for each patient and factors predictive of sustained response were investigated. Adverse events were also identified. Results: The median duration of follow-up after initial infliximab infusion was of 29.5 months. The clinical response rates at 2, 4, 30, and 54 weeks were 75%, 64.3%, 50%, and 39.1%, respectively, with clinical remission rates of 32.1%, 28.6%, 46.2%, and 39.1%, respectively. After multivariate analysis, older age at diagnosis (≥40 yr), female sex, a longer disease duration (≥5 yr), concomitant immunomodulator use, and achievement of remission at week 4 were found to be predictive factors of sustained response. There was 1 serious infection but no malignancies or deaths in this study. Conclusions: Infliximab was a well-tolerated and effective therapy for patients with moderate-to-severe intestinal BD. Moreover, we found 5 predictive factors associated with sustained response, which might assist in optimal patient selection for infliximab treatment.

Original languageEnglish
Pages (from-to)1833-1838
Number of pages6
JournalInflammatory Bowel Diseases
Volume19
Issue number9
DOIs
Publication statusPublished - 2013 Aug

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Gastroenterology

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    Lee, J. H., Cheon, J. H., Jeon, S. W., Ye, B. D., Yang, S. K., Kim, Y. H., Lee, K. M., Im, J. P., Kim, J. S., Lee, C. K., Kim, H. J., Kim, E. Y., Kim, K. O., Jang, B. I., & Kim, W. H. (2013). Efficacy of infliximab in intestinal Behçet's disease: A Korean multicenter retrospective study. Inflammatory Bowel Diseases, 19(9), 1833-1838. https://doi.org/10.1097/MIB.0b013e31828f19c9