Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment

Ji Young Hong, Hye Jon Lee, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sang Nae Cho, Young Ae Kang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. Results: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P<0.001; median: 140.4 and 105.7pg/ml, respectively) and TB antigen-dependent IP-10 (P=0.002; median: 20,000 and 13,720pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P=0.35), whereas the proportion of serum IP-10 responders was significantly different (P=0.001). Conclusions: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB.

Original languageEnglish
Pages (from-to)252-258
Number of pages7
JournalJournal of Infection
Volume68
Issue number3
DOIs
Publication statusPublished - 2014 Mar 1

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Tuberculosis
Biomarkers
Antigens
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Hong, J. Y., Lee, H. J., Kim, S. Y., Chung, K. S., Kim, E. Y., Jung, J. Y., ... Kang, Y. A. (2014). Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment. Journal of Infection, 68(3), 252-258. https://doi.org/10.1016/j.jinf.2013.09.033
Hong, Ji Young ; Lee, Hye Jon ; Kim, Song Yee ; Chung, Kyung Soo ; Kim, Eun Young ; Jung, Ji Ye ; Park, Moo Suk ; Kim, Young Sam ; Kim, Se Kyu ; Chang, Joon ; Cho, Sang Nae ; Kang, Young Ae. / Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment. In: Journal of Infection. 2014 ; Vol. 68, No. 3. pp. 252-258.
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Hong, JY, Lee, HJ, Kim, SY, Chung, KS, Kim, EY, Jung, JY, Park, MS, Kim, YS, Kim, SK, Chang, J, Cho, SN & Kang, YA 2014, 'Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment', Journal of Infection, vol. 68, no. 3, pp. 252-258. https://doi.org/10.1016/j.jinf.2013.09.033

Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment. / Hong, Ji Young; Lee, Hye Jon; Kim, Song Yee; Chung, Kyung Soo; Kim, Eun Young; Jung, Ji Ye; Park, Moo Suk; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Cho, Sang Nae; Kang, Young Ae.

In: Journal of Infection, Vol. 68, No. 3, 01.03.2014, p. 252-258.

Research output: Contribution to journalArticle

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AU - Park, Moo Suk

AU - Kim, Young Sam

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AU - Kang, Young Ae

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N2 - Objectives: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. Results: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P<0.001; median: 140.4 and 105.7pg/ml, respectively) and TB antigen-dependent IP-10 (P=0.002; median: 20,000 and 13,720pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P=0.35), whereas the proportion of serum IP-10 responders was significantly different (P=0.001). Conclusions: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB.

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Hong JY, Lee HJ, Kim SY, Chung KS, Kim EY, Jung JY et al. Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment. Journal of Infection. 2014 Mar 1;68(3):252-258. https://doi.org/10.1016/j.jinf.2013.09.033