Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment

Ji Young Hong, Hye Jon Lee, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sang Nae Cho, Young Ae Kang

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29 Citations (Scopus)

Abstract

Objectives: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. Results: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P<0.001; median: 140.4 and 105.7pg/ml, respectively) and TB antigen-dependent IP-10 (P=0.002; median: 20,000 and 13,720pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P=0.35), whereas the proportion of serum IP-10 responders was significantly different (P=0.001). Conclusions: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB.

Original languageEnglish
Pages (from-to)252-258
Number of pages7
JournalJournal of Infection
Volume68
Issue number3
DOIs
Publication statusPublished - 2014 Mar 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Hong, J. Y., Lee, H. J., Kim, S. Y., Chung, K. S., Kim, E. Y., Jung, J. Y., Park, M. S., Kim, Y. S., Kim, S. K., Chang, J., Cho, S. N., & Kang, Y. A. (2014). Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment. Journal of Infection, 68(3), 252-258. https://doi.org/10.1016/j.jinf.2013.09.033