Objectives: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. Results: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P<0.001; median: 140.4 and 105.7pg/ml, respectively) and TB antigen-dependent IP-10 (P=0.002; median: 20,000 and 13,720pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P=0.35), whereas the proportion of serum IP-10 responders was significantly different (P=0.001). Conclusions: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB.
Bibliographical noteFunding Information:
This study was supported by a grant from the Korean Health Technology R&D Project, Ministry for Health, Welfare, and Family Affairs, Republic of Korea ( A101750 ). The funding source had no role in the study process, including the design, sample collection, analysis, and interpretation of the results.
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases