Efficiency factors of singlet oxygen generation from core-modified expanded porphyrin: Tetrathiarubyrin in ethanol

Jeong Hyon Ha, Young Jung Gook, Min Sun Kim, Hoon Lee Yang, Koo Shin, Yong Rok Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The photophysical properties and the singlet oxygen generation efficiency of tetrathiarubyrin have been investigated to elucidate the possibility of its use as a photodynamic therapy (PDT) photosensitizer by steady-state and time-resolved spectroscopic methods. The observed photophysical properties were affected by various molecular aspects, such as extended π conjugation, structural distortion, and internal heavy atom. The steady-state electronic absorption spectrum was red-shifted due to the extended π-conjugation, and the spin orbital coupling was enhanced by the structural distortion and the internal heavy atom effect. As a result of the enhanced spin orbital coupling, the triplet quantum yield increased to 0.90 ± 0.10 and the triplet state lifetime was shortened to 7.0 ± 1.2 μs. Since the triplet state decays at a relatively faster rate, the efficiency of the oxygen quenching of the triplet state decreases. The singlet oxygen quantum yield was estimated to be 0.52 ± 0.02, which is somewhat lower than expected. On the other hand, the efficiency of singlet oxygen generation during the oxygen quenching of triplet state, fδT, is near unity. Such high efficiency of singlet oxygen generation can be explained by the following two possible factors: The hydrogen bonding of ethanol which impedes the deactivation pathway of the charge transfer complex with oxygen to the ground state, the less probability of the aggregation formation.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume22
Issue number1
Publication statusPublished - 2001 Jan 20

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Singlet Oxygen
Porphyrins
Ethanol
Quantum yield
Oxygen
Quenching
Atoms
Photodynamic therapy
Photosensitizing Agents
Electronic states
Ground state
Charge transfer
Absorption spectra
Hydrogen bonds
Agglomeration

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Ha, Jeong Hyon ; Gook, Young Jung ; Kim, Min Sun ; Yang, Hoon Lee ; Shin, Koo ; Kim, Yong Rok. / Efficiency factors of singlet oxygen generation from core-modified expanded porphyrin : Tetrathiarubyrin in ethanol. In: Bulletin of the Korean Chemical Society. 2001 ; Vol. 22, No. 1. pp. 63-67.
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abstract = "The photophysical properties and the singlet oxygen generation efficiency of tetrathiarubyrin have been investigated to elucidate the possibility of its use as a photodynamic therapy (PDT) photosensitizer by steady-state and time-resolved spectroscopic methods. The observed photophysical properties were affected by various molecular aspects, such as extended π conjugation, structural distortion, and internal heavy atom. The steady-state electronic absorption spectrum was red-shifted due to the extended π-conjugation, and the spin orbital coupling was enhanced by the structural distortion and the internal heavy atom effect. As a result of the enhanced spin orbital coupling, the triplet quantum yield increased to 0.90 ± 0.10 and the triplet state lifetime was shortened to 7.0 ± 1.2 μs. Since the triplet state decays at a relatively faster rate, the efficiency of the oxygen quenching of the triplet state decreases. The singlet oxygen quantum yield was estimated to be 0.52 ± 0.02, which is somewhat lower than expected. On the other hand, the efficiency of singlet oxygen generation during the oxygen quenching of triplet state, fδT, is near unity. Such high efficiency of singlet oxygen generation can be explained by the following two possible factors: The hydrogen bonding of ethanol which impedes the deactivation pathway of the charge transfer complex with oxygen to the ground state, the less probability of the aggregation formation.",
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Efficiency factors of singlet oxygen generation from core-modified expanded porphyrin : Tetrathiarubyrin in ethanol. / Ha, Jeong Hyon; Gook, Young Jung; Kim, Min Sun; Yang, Hoon Lee; Shin, Koo; Kim, Yong Rok.

In: Bulletin of the Korean Chemical Society, Vol. 22, No. 1, 20.01.2001, p. 63-67.

Research output: Contribution to journalArticle

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T1 - Efficiency factors of singlet oxygen generation from core-modified expanded porphyrin

T2 - Tetrathiarubyrin in ethanol

AU - Ha, Jeong Hyon

AU - Gook, Young Jung

AU - Kim, Min Sun

AU - Yang, Hoon Lee

AU - Shin, Koo

AU - Kim, Yong Rok

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N2 - The photophysical properties and the singlet oxygen generation efficiency of tetrathiarubyrin have been investigated to elucidate the possibility of its use as a photodynamic therapy (PDT) photosensitizer by steady-state and time-resolved spectroscopic methods. The observed photophysical properties were affected by various molecular aspects, such as extended π conjugation, structural distortion, and internal heavy atom. The steady-state electronic absorption spectrum was red-shifted due to the extended π-conjugation, and the spin orbital coupling was enhanced by the structural distortion and the internal heavy atom effect. As a result of the enhanced spin orbital coupling, the triplet quantum yield increased to 0.90 ± 0.10 and the triplet state lifetime was shortened to 7.0 ± 1.2 μs. Since the triplet state decays at a relatively faster rate, the efficiency of the oxygen quenching of the triplet state decreases. The singlet oxygen quantum yield was estimated to be 0.52 ± 0.02, which is somewhat lower than expected. On the other hand, the efficiency of singlet oxygen generation during the oxygen quenching of triplet state, fδT, is near unity. Such high efficiency of singlet oxygen generation can be explained by the following two possible factors: The hydrogen bonding of ethanol which impedes the deactivation pathway of the charge transfer complex with oxygen to the ground state, the less probability of the aggregation formation.

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