Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment

Haejin Chun, Minjoo Yeom, Hyun Ouk Kim, Jong Woo Lim, Woonsung Na, Geunseon Park, Chaewon Park, Aram Kang, Dayeon Yun, Jihye Kim, Daesub Song, Seungjoo Haam

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Influenza A virus (IAV), which causes one of the most contagious diseases, is a global health concern and is responsible for seasonal epidemics and pandemics. Despite notable efforts towards developing antiviral agents and drugs, a vast majority of these, especially intracellular drugs, have shown limited efficacy due to non-specificity and low viability under physiological or endosomal conditions. Polymersomes consist of phenylboronic acid (PBA) pendant group polymers (PBASomes) and can act as drug carriers; they have sialic acid-targeting properties and can gain greater access to the intracellular space for the transport of antivirals within the host cell. Amphiphilic copolymers comprising methoxy-poly(ethylene glycol)-block-poly(phenylalanine) (mPEG-b-pPhe) formed polymersomes, which encapsulated mir-323a in the core and favipiravir in the exterior layer as hydrophilic and hydrophobic antivirals, respectively. For maximizing the cellular uptake of PBASomes via receptor-mediated endocytosis, the surface density of PBA was controlled with PBA-functionalized copolymers (PBA-PEG-pPhe). Combination therapy by employing polymersomes with PBA functional groups induced a synergistic effect against H1N1 virus infection in vitro. We believe that antiviral co-delivery using these polymersomes would provide better opportunities to improve transfection of therapeutic substances for IAV treatment.

Original languageEnglish
Pages (from-to)2116-2123
Number of pages8
JournalPolymer Chemistry
Volume9
Issue number16
DOIs
Publication statusPublished - 2018 Apr 28

Bibliographical note

Funding Information:
This research was supported by the BioNano Health-Guard Research Center funded by the Ministry of Science and ICT (MSIT) of Korea as a Global Frontier Project (Grant number H-GUARD_2013M3A6B2078946).

Publisher Copyright:
© The Royal Society of Chemistry 2018.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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