Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment

Haejin Chun, Minjoo Yeom, Hyun Ouk Kim, Jong Woo Lim, Woonsung Na, Geunseon Park, Chaewon Park, Aram Kang, Dayeon Yun, Jihye Kim, Daesub Song, Seungjoo Haam

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Influenza A virus (IAV), which causes one of the most contagious diseases, is a global health concern and is responsible for seasonal epidemics and pandemics. Despite notable efforts towards developing antiviral agents and drugs, a vast majority of these, especially intracellular drugs, have shown limited efficacy due to non-specificity and low viability under physiological or endosomal conditions. Polymersomes consist of phenylboronic acid (PBA) pendant group polymers (PBASomes) and can act as drug carriers; they have sialic acid-targeting properties and can gain greater access to the intracellular space for the transport of antivirals within the host cell. Amphiphilic copolymers comprising methoxy-poly(ethylene glycol)-block-poly(phenylalanine) (mPEG-b-pPhe) formed polymersomes, which encapsulated mir-323a in the core and favipiravir in the exterior layer as hydrophilic and hydrophobic antivirals, respectively. For maximizing the cellular uptake of PBASomes via receptor-mediated endocytosis, the surface density of PBA was controlled with PBA-functionalized copolymers (PBA-PEG-pPhe). Combination therapy by employing polymersomes with PBA functional groups induced a synergistic effect against H1N1 virus infection in vitro. We believe that antiviral co-delivery using these polymersomes would provide better opportunities to improve transfection of therapeutic substances for IAV treatment.

Original languageEnglish
Pages (from-to)2116-2123
Number of pages8
JournalPolymer Chemistry
Volume9
Issue number16
DOIs
Publication statusPublished - 2018 Apr 28

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Influenza A virus
Viruses
Antiviral Agents
Cell Count
Acids
Copolymers
Polyethylene glycols
Intracellular Space
Antiviral agents
Therapeutics
H1N1 Subtype Influenza A Virus
Drug Carriers
N-Acetylneuraminic Acid
Pandemics
Virus Diseases
Endocytosis
Functional groups
Transfection
Polymers
benzeneboronic acid

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Chun, Haejin ; Yeom, Minjoo ; Kim, Hyun Ouk ; Lim, Jong Woo ; Na, Woonsung ; Park, Geunseon ; Park, Chaewon ; Kang, Aram ; Yun, Dayeon ; Kim, Jihye ; Song, Daesub ; Haam, Seungjoo. / Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment. In: Polymer Chemistry. 2018 ; Vol. 9, No. 16. pp. 2116-2123.
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abstract = "Influenza A virus (IAV), which causes one of the most contagious diseases, is a global health concern and is responsible for seasonal epidemics and pandemics. Despite notable efforts towards developing antiviral agents and drugs, a vast majority of these, especially intracellular drugs, have shown limited efficacy due to non-specificity and low viability under physiological or endosomal conditions. Polymersomes consist of phenylboronic acid (PBA) pendant group polymers (PBASomes) and can act as drug carriers; they have sialic acid-targeting properties and can gain greater access to the intracellular space for the transport of antivirals within the host cell. Amphiphilic copolymers comprising methoxy-poly(ethylene glycol)-block-poly(phenylalanine) (mPEG-b-pPhe) formed polymersomes, which encapsulated mir-323a in the core and favipiravir in the exterior layer as hydrophilic and hydrophobic antivirals, respectively. For maximizing the cellular uptake of PBASomes via receptor-mediated endocytosis, the surface density of PBA was controlled with PBA-functionalized copolymers (PBA-PEG-pPhe). Combination therapy by employing polymersomes with PBA functional groups induced a synergistic effect against H1N1 virus infection in vitro. We believe that antiviral co-delivery using these polymersomes would provide better opportunities to improve transfection of therapeutic substances for IAV treatment.",
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Chun, H, Yeom, M, Kim, HO, Lim, JW, Na, W, Park, G, Park, C, Kang, A, Yun, D, Kim, J, Song, D & Haam, S 2018, 'Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment', Polymer Chemistry, vol. 9, no. 16, pp. 2116-2123. https://doi.org/10.1039/c8py00116b

Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment. / Chun, Haejin; Yeom, Minjoo; Kim, Hyun Ouk; Lim, Jong Woo; Na, Woonsung; Park, Geunseon; Park, Chaewon; Kang, Aram; Yun, Dayeon; Kim, Jihye; Song, Daesub; Haam, Seungjoo.

In: Polymer Chemistry, Vol. 9, No. 16, 28.04.2018, p. 2116-2123.

Research output: Contribution to journalArticle

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AU - Chun, Haejin

AU - Yeom, Minjoo

AU - Kim, Hyun Ouk

AU - Lim, Jong Woo

AU - Na, Woonsung

AU - Park, Geunseon

AU - Park, Chaewon

AU - Kang, Aram

AU - Yun, Dayeon

AU - Kim, Jihye

AU - Song, Daesub

AU - Haam, Seungjoo

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