Efficient solid-phase synthesis of trifunctional probes and their application to the detection of carbohydrate-binding proteins

Myung Ryul Lee, Da Woon Jung, Darren Williams, Injae Shin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

(Chemical Equation Presented) An efficient solid-phase synthesis of trifunctional probes containing a photoreactive group, a reporter tag, and a carbohydrate ligand was developed. Labeling studies with these probes demonstrate that specific lectins can be labeled with high sensitivity and selectivity. This technique serves as a powerful tool for the rapid detection and profiling of lectins.

Original languageEnglish
Pages (from-to)5477-5480
Number of pages4
JournalOrganic Letters
Volume7
Issue number24
DOIs
Publication statusPublished - 2005 Nov 24

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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