Efficient solid-phase synthesis of trifunctional probes and their application to the detection of carbohydrate-binding proteins

Myung Ryul Lee; Da Woon Jung; Darren Williams; Injae Shin

doi:10.1021/ol0523188

Efficient solid-phase synthesis of trifunctional probes and their application to the detection of carbohydrate-binding proteins

Myung Ryul Lee, Da Woon Jung, Darren Williams, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

(Chemical Equation Presented) An efficient solid-phase synthesis of trifunctional probes containing a photoreactive group, a reporter tag, and a carbohydrate ligand was developed. Labeling studies with these probes demonstrate that specific lectins can be labeled with high sensitivity and selectivity. This technique serves as a powerful tool for the rapid detection and profiling of lectins.

Original language	English
Pages (from-to)	5477-5480
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	24
DOIs	https://doi.org/10.1021/ol0523188
Publication status	Published - 2005 Nov 24

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0523188

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AB - (Chemical Equation Presented) An efficient solid-phase synthesis of trifunctional probes containing a photoreactive group, a reporter tag, and a carbohydrate ligand was developed. Labeling studies with these probes demonstrate that specific lectins can be labeled with high sensitivity and selectivity. This technique serves as a powerful tool for the rapid detection and profiling of lectins.

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Efficient solid-phase synthesis of trifunctional probes and their application to the detection of carbohydrate-binding proteins

Abstract

All Science Journal Classification (ASJC) codes

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