Efficient synthesis of highly substituted indolizinones via iodocyclization and 1,2-shift

Jihyun Choi, Hyeong Lee Ge, Ikyon Kim

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Abstract

The 5-endo-dig iodocyclization of propargylic alcohols followed by a 1,2-shift provided rapid access to 2-iodoindolizinones, while the 5-endo-trig iodocyclization of allylic alcohols and subsequent dehydroiodination and 1,2-shift led to indolizinones. A number of highly substituted indolizinones were constructed under these mild reaction conditions.

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalSynlett
Issue number8
DOIs
Publication statusPublished - 2008 May 5

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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