Efficient synthesis of highly substituted indolizinones via iodocyclization and 1,2-shift

Jihyun Choi; Hyeong Lee Ge; Ikyon Kim

doi:10.1055/s-2008-1072721

Efficient synthesis of highly substituted indolizinones via iodocyclization and 1,2-shift

Jihyun Choi, Hyeong Lee Ge, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The 5-endo-dig iodocyclization of propargylic alcohols followed by a 1,2-shift provided rapid access to 2-iodoindolizinones, while the 5-endo-trig iodocyclization of allylic alcohols and subsequent dehydroiodination and 1,2-shift led to indolizinones. A number of highly substituted indolizinones were constructed under these mild reaction conditions.

Original language	English
Pages (from-to)	1243-1249
Number of pages	7
Journal	Synlett
Issue number	8
DOIs	https://doi.org/10.1055/s-2008-1072721
Publication status	Published - 2008 May 5

All Science Journal Classification (ASJC) codes

Organic Chemistry

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abstract = "The 5-endo-dig iodocyclization of propargylic alcohols followed by a 1,2-shift provided rapid access to 2-iodoindolizinones, while the 5-endo-trig iodocyclization of allylic alcohols and subsequent dehydroiodination and 1,2-shift led to indolizinones. A number of highly substituted indolizinones were constructed under these mild reaction conditions.",

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AB - The 5-endo-dig iodocyclization of propargylic alcohols followed by a 1,2-shift provided rapid access to 2-iodoindolizinones, while the 5-endo-trig iodocyclization of allylic alcohols and subsequent dehydroiodination and 1,2-shift led to indolizinones. A number of highly substituted indolizinones were constructed under these mild reaction conditions.

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Efficient synthesis of highly substituted indolizinones via iodocyclization and 1,2-shift

Abstract

All Science Journal Classification (ASJC) codes

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